2026-06-30T04:06:48Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/68282024-11-28T17:35:56Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16961col_20.500.12105_16971
Repisalud
author
Pernas, Maria
author
Casado, Concepcion
author
Arcones, Carolina
author
Llano, Anuska
author
Sanchez-Merino, Victor
author
Mothe, Beatriz
author
Vicario, José L
author
Grau, Eulalia
author
Ruiz, Lidia
author
Sánchez, Jorge
author
Telenti, Amalio
author
Yuste-Herranz, Maria Eloisa
author
Brander, Christian
author
Lopez-Galindez, Luis Cecilio
funder
Ministerio de Economía y Competitividad (España)
funder
Fundación para la Investigación y la Prevención del Sida en España
funder
National Institutes of Health (Estados Unidos)
funder
Instituto de Salud Carlos III
2018-12-12T15:01:22Z
2018-12-12T15:01:22Z
2012-02-24
PLoS One. 2012;7(2):e31928
10.1371/journal.pone.0031928
1932-6203
1932-6203
PloS one
22384103
http://hdl.handle.net/20.500.12105/6828
OBJECTIVE: To study the causes for the lack of clinical progression in a superinfected HIV-1 LTNP elite controller patient. METHODOLOGY AND PRINCIPAL FINDINGS: We studied host genetic, virological and immunological factors associated with viral control in a SI long term non progressor elite controller (LTNP-EC). The individual contained both viruses and maintained undetectable viral loads for >20 years and he did not express any of the described host genetic polymorphisms associated with viral control. None of four full-length gp160 recombinants derived from the LTNP-EC replicated in heterologous peripheral blood mononuclear cells. CTL responses after SI were maintained in two samples separated by 9 years and they were higher in breadth and magnitude than responses seen in most of 250 treatment naïve patients and also 25 controller subjects. The LTNP-EC showed a neutralization response, against 4 of the 6 viruses analyzed, superior to other ECs. CONCLUSIONS: The study demonstrated that a strong and sustained cellular and humoral immune response and low replicating viruses are associated with viral control in the superinfected LTNP-EC.
eng
Low-replicating viruses and strong anti-viral immune response associated with prolonged disease control in a superinfected HIV-1 LTNP elite controller
journal article
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URL
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File
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application/pdf
Low-ReplicatingVirusesAndStrong_2012.pdf
URL
https://repisalud.isciii.es/bitstreams/ff0b0272-fedf-4e60-8bb2-18a938b11bdd/download
File
MD5
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text/plain
Low-ReplicatingVirusesAndStrong_2012.pdf.txt