2026-06-30T04:06:47Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/68282024-11-28T17:35:56Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16961col_20.500.12105_16971

00925njm 22002777a 4500 dc Pernas, Maria author Casado, Concepcion author Arcones, Carolina author Llano, Anuska author Sanchez-Merino, Victor author Mothe, Beatriz author Vicario, José L author Grau, Eulalia author Ruiz, Lidia author Sánchez, Jorge author Telenti, Amalio author Yuste-Herranz, Maria Eloisa author Brander, Christian author Lopez-Galindez, Luis Cecilio author 2012-02-24 OBJECTIVE: To study the causes for the lack of clinical progression in a superinfected HIV-1 LTNP elite controller patient. METHODOLOGY AND PRINCIPAL FINDINGS: We studied host genetic, virological and immunological factors associated with viral control in a SI long term non progressor elite controller (LTNP-EC). The individual contained both viruses and maintained undetectable viral loads for >20 years and he did not express any of the described host genetic polymorphisms associated with viral control. None of four full-length gp160 recombinants derived from the LTNP-EC replicated in heterologous peripheral blood mononuclear cells. CTL responses after SI were maintained in two samples separated by 9 years and they were higher in breadth and magnitude than responses seen in most of 250 treatment naïve patients and also 25 controller subjects. The LTNP-EC showed a neutralization response, against 4 of the 6 viruses analyzed, superior to other ECs. CONCLUSIONS: The study demonstrated that a strong and sustained cellular and humoral immune response and low replicating viruses are associated with viral control in the superinfected LTNP-EC. PLoS One. 2012;7(2):e31928 10.1371/journal.pone.0031928 1932-6203 1932-6203 PloS one 22384103 http://hdl.handle.net/20.500.12105/6828 Low-replicating viruses and strong anti-viral immune response associated with prolonged disease control in a superinfected HIV-1 LTNP elite controller