2026-06-14T03:32:28Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/68162024-09-27T16:35:19Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608

00925njm 22002777a 4500 dc Márquez-Rodas, Iván author Pollan-Santamaria, Marina author Escudero, María José author Ruiz, Amparo author Martín, Miguel author Santaballa, Ana author Martínez Del Prado, Purificación author Batista, Norberto author Andrés, Raquel author Antón, Antonio author Llombart, Antonio author Fernandez Aramburu, Antonio author Adrover, Encarna author González, Sonia author Seguí, Miguel Angel author Calvo, Lourdes author Lizón, José author Rodríguez Lescure, Álvaro author Ramón Y Cajal, Teresa author Llort, Gemma author Jara, Carlos author Carrasco, Eva author López-Tarruella, Sara author 2017-10-05 PURPOSE: To determine the frequency of breast cancer (BC) patients with hereditary risk features in a wide retrospective cohort of patients in Spain. METHODS: a retrospective analysis was conducted from 10,638 BC patients diagnosed between 1998 and 2001 in the GEICAM registry "El Álamo III", dividing them into four groups according to modified ESMO and SEOM hereditary cancer risk criteria: Sporadic breast cancer group (R0); Individual risk group (IR); Familial risk group (FR); Individual and familial risk group (IFR) with both individual and familial risk criteria. RESULTS: 7,641 patients were evaluable. Of them, 2,252 patients (29.5%) had at least one hereditary risk criteria, being subclassified in: FR 1.105 (14.5%), IR 970 (12.7%), IFR 177 (2.3%). There was a higher frequency of newly diagnosed metastatic patients in the IR group (5.1% vs 3.2%, p = 0.02). In contrast, in RO were lower proportion of big tumors (> T2) (43.8% vs 47.4%, p = 0.023), nodal involvement (43.4% vs 48.1%, p = 0.004) and lower histological grades (20.9% G3 for the R0 vs 29.8%) when compared to patients with any risk criteria. CONCLUSIONS: Almost three out of ten BC patients have at least one hereditary risk cancer feature that would warrant further genetic counseling. Patients with hereditary cancer risk seems to be diagnosed with worse prognosis factors. PLoS One. 2017 Oct 6;12(10):e0184181. 10.1371/journal.pone.0184181 1932-6203 1932-6203 PloS one 28985233 http://hdl.handle.net/20.500.12105/6816 Frequency of breast cancer with hereditary risk features in Spain: Analysis from GEICAM "El Álamo III" retrospective study