2026-05-17T05:49:18Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/68072025-04-01T08:36:01Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_19609col_20.500.12105_16968
Repisalud
author
Gherasim, Alin Manuel
author
Martínez-Baz, Iván
author
Castilla Catalán, Jesús
author
Pozo Sanchez, Francisco
author
Larrauri, Amparo
author
cycEVA working group
author
Jimenez-Jorge, Silvia
author
Mateo-Ontañon, Salvador de
author
Delgado-Sanz, Concepcion
author
Oliva Dominguez, Jesus Angel
author
Savulescu, Camelia
author
Casas Flecha, Inmaculada
author
Garcia-Cenoz, Manuel
funder
Unión Europea. Comisión Europea
funder
Unión Europea. European Centre for Disease Prevention and Control (ECDC)
2018-12-11T12:24:32Z
2018-12-11T12:24:32Z
2017-06-14
PLoS One. 2017 Jun 14;12(6):e0179160.
10.1371/journal.pone.0179160
1932-6203
1932-6203
PloS one
28614376
http://hdl.handle.net/20.500.12105/6807
BACKGROUND: Recent studies suggest that the protective effect of the current influenza vaccine could be influenced by vaccination in previous seasons. We estimated the combined effect of the previous and current influenza vaccines from the 2010-2011 season to the 2015-2016 season in Spain. METHODS: We performed a test-negative case-control study in patients ≥9 years old. We estimated the influenza vaccine effectiveness (IVE) against influenza A(H1N1)pdm09, A(H3N2), and B virus. RESULTS: We included 1206 influenza A(H1N1)pdm09 cases, 1358 A(H3N2) cases and 1079 B cases. IVE against A(H1N1)pdm09 virus in the pooled-season analysis was 53% (95% Confidence Interval (CI): 21% to 72%) for those vaccinated only in the current season and 50% (95%CI: 23% to 68%) for those vaccinated in the both current and previous seasons. Against the influenza A(H3N2) virus, IVE was 17% (95%CI: -43% to 52%) for those vaccinated only in the current season and 3% (95%CI: -33% to 28%) for those vaccinated in both seasons. Regarding influenza B, we obtained similar IVEs for those vaccinated only in the current and those vaccinated in both seasons: 57% (95%CI: 12% to 79%) and 56% (95%CI: 36% to 70%), respectively. CONCLUSION: Our results suggested no interference between the previous and current influenza vaccines against A(H1N1)pdm09 and B viruses, but a possible negative interference against A(H3N2) virus.
eng
Effect of previous and current vaccination against influenza A(H1N1)pdm09, A(H3N2), and B during the post-pandemic period 2010-2016 in Spain
research article
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EffectOfPreviousAnd_2018.pdf
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EffectOfPreviousAnd_2018.pdf.txt