2026-08-29T14:07:30Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/67902025-05-08T07:48:02Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_16974
Repisalud
author
Quintana, Jose Maria
author
Antón-Ladislao, Ane
author
González, Nerea
author
Lázaro, Santiago
author
Baré, Marisa
author
Fernandez de Larrea-Baz, Nerea
author
Redondo, Maximino
author
Briones, Eduardo
author
Escobar, Antonio
author
Sarasqueta, Cristina
author
García-Gutierrez, Susana
author
Aróstegui, Inmaculada
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Instituto de Salud Carlos III
funder
Basque Government (España)
funder
RETICS-Servicios de Salud Orientados a Enfermedades Crónicas (REDISSEC-ISCIII) (España)
2018-12-07T13:41:55Z
2018-12-07T13:41:55Z
2018-06-28
PLoS One. 2018 Jun 28;13(6):e0199894.
10.1371/journal.pone.0199894
1932-6203
1932-6203
PloS one
29953553
http://hdl.handle.net/20.500.12105/6790
BACKGROUND: Tools to aid in the prognosis assessment of colon cancer patients in terms of risk of mortality are needed. Goals of this study are to develop and validate clinical prediction rules for 1- and 2-year mortality in these patients. METHODS: This is a prospective cohort study of patients diagnosed with colon cancer who underwent surgery at 22 hospitals. The main outcomes were mortality at 1 and 2 years after surgery. Background, clinical parameters, and diagnostic tests findings were evaluated as possible predictors. Multivariable multilevel logistic regression and survival models were used in the analyses to create the clinical prediction rules. Models developed in the derivation sample were validated in another sample of the study. RESULTS: American Society of Anesthesiologists Physical Status Classification System (ASA), Charlson comorbidity index (> = 4), age (>75 years), residual tumor (R2), TNM stage IV and log of lymph nodes ratio (> = -0.53) were predictors of 1-year mortality (C-index (95% CI): 0.865 (0.792-0.938)). Adjuvant chemotherapy was an additional predictor. Again ASA, Charlson Index (> = 4), age (>75 years), log of lymph nodes ratio (> = -0.53), TNM, and residual tumor were predictors of 2-year mortality (C-index:0.821 (0.766-0.876). Chemotherapy was also an additional predictor. CONCLUSIONS: These clinical prediction rules show very good predictive abilities of one and two years survival and provide clinicians and patients with an easy and quick-to-use decision tool for use in the clinical decision process while the patient is still in the index admission.
eng
Predictors of one and two years' mortality in patients with colon cancer: A prospective cohort study
research article
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URL
https://repisalud.isciii.es/bitstreams/0426b150-937b-4337-beef-165b77233152/download
File
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application/pdf
PredictorsOfneAnd_2018.pdf
URL
https://repisalud.isciii.es/bitstreams/e1fb9eef-0722-4e62-97c8-fb30f0babb7d/download
File
MD5
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text/plain
PredictorsOfneAnd_2018.pdf.txt