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oai:repisalud.isciii.es:20.500.12105/67882024-09-27T21:02:55Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Franco, Leticia author Palacios, Gustavo author Martinez, José Antonio author Vazquez, Ana author Savji, Nazir author De Ory, Fernando de author Sánchez-Seco, María Paz author Martín, Dolores author Lipkin, W Ian author Tenorio, Antonio author 2011-08-02 Dengue virus (DENV) circulates in human and sylvatic cycles. Sylvatic strains are both ecologically and evolutionarily distinct from endemic viruses. Although sylvatic dengue cycles occur in West African countries and Malaysia, only a few cases of mild human disease caused by sylvatic strains and one single case of dengue hemorrhagic fever in Malaysia have been reported. Here we report a case of dengue hemorrhagic fever (DHF) with thrombocytopenia (13000/µl), a raised hematocrit (32% above baseline) and mucosal bleeding in a 27-year-old male returning to Spain in November 2009 after visiting his home country Guinea Bissau. Sylvatic DENV-2 West African lineage was isolated from blood and sera. This is the first case of DHF associated with sylvatic DENV-2 in Africa and the second case worldwide of DHF caused by a sylvatic strain. PLoS Negl Trop Dis. 2011 Aug;5(8):e1251. 10.1371/journal.pntd.0001251 1935-2735 1935-2735 PLoS neglected tropical diseases 21829739 http://hdl.handle.net/20.500.12105/6788 First report of sylvatic DENV-2-associated dengue hemorrhagic fever in West Africa