2026-06-14T03:29:00Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/67732024-11-29T13:43:14Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_2173col_20.500.12105_19609col_20.500.12105_19597
Repisalud
author
Abarrategi, Ander
author
Moreno-Vicente, Carolina
author
Martínez-Vázquez, Francisco Javier
author
Civantos, Ana
author
Ramos, Viviana
author
Sanz-Casado, José Vicente
author
Martínez-Corriá, Ramón
author
Perera, Fidel Hugo
author
Mulero, Francisca
author
Miranda, Pedro
author
López-Lacomba, José Luís
funder
Ministerio de Ciencia e Innovación (España)
funder
Ministerio de Educación y Ciencia (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
2018-12-05T19:30:43Z
2018-12-05T19:30:43Z
2012-03-28
PLoS One. 2012;7(3):e34117
10.1371/journal.pone.0034117
1932-6203
1932-6203
PloS one
22470527
http://hdl.handle.net/20.500.12105/6773
Porous ceramic scaffolds are widely studied in the tissue engineering field due to their potential in medical applications as bone substitutes or as bone-filling materials. Solid free form (SFF) fabrication methods allow fabrication of ceramic scaffolds with fully controlled pore architecture, which opens new perspectives in bone tissue regeneration materials. However, little experimentation has been performed about real biological properties and possible applications of SFF designed 3D ceramic scaffolds. Thus, here the biological properties of a specific SFF scaffold are evaluated first, both in vitro and in vivo, and later scaffolds are also implanted in pig maxillary defect, which is a model for a possible application in maxillofacial surgery. In vitro results show good biocompatibility of the scaffolds, promoting cell ingrowth. In vivo results indicate that material on its own conducts surrounding tissue and allow cell ingrowth, thanks to the designed pore size. Additional osteoinductive properties were obtained with BMP-2, which was loaded on scaffolds, and optimal bone formation was observed in pig implantation model. Collectively, data show that SFF scaffolds have real application possibilities for bone tissue engineering purposes, with the main advantage of being fully customizable 3D structures.
eng
Biological properties of solid free form designed ceramic scaffolds with BMP-2: in vitro and in vivo evaluation
journal article
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URL
https://repisalud.isciii.es/bitstreams/ca09d4d5-3bc4-4b44-b1d4-0618ea446b67/download
File
MD5
4d163367ee628730ec5688ca9e3f40c7
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application/pdf
BiologicalPropertiesOfSolid_2012.pdf
URL
https://repisalud.isciii.es/bitstreams/724ef9b4-dcf1-42e3-9a59-594d0eaad57f/download
File
MD5
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text/plain
BiologicalPropertiesOfSolid_2012.pdf.txt