2026-05-17T10:14:06Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/67682025-06-18T08:45:18Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608col_20.500.12105_19613
Repisalud
author
Fuente, Luis de la
author
Rosales-Statkus, Maria-Elena
author
Hoyos, Juan
author
Pulido, Jose
author
Santos, Sara
author
Bravo, Maria Jose
author
Barrio, Gregorio
author
Fernandez-Balbuena, Sonia
author
Belza Egozcue, Maria Jose
funder
Fundación para la Investigación y la Prevención del Sida en España
funder
Instituto de Salud Carlos III
2018-12-05T18:19:39Z
2018-12-05T18:19:39Z
2012-10-08
PLoS One. 2012;7(10):e46555.
10.1371/journal.pone.0046555
1932-6203
1932-6203
PloS one
23056342
http://hdl.handle.net/20.500.12105/6768
OBJECTIVE: Availability of over-the-counter rapid HIV tests could improve access to testing those reluctant or unable to use current services. We aimed to evaluate the feasibility of HIV self-testing using a finger-stick whole-blood rapid test (Determine™ HIV Combo) to detect both antigen and antibody. METHODS: Before being tested, 313 participants in a street-based testing program were given adapted instructions and a test kit, and performed the self-test without supervision. These participants, together with another 207 who performed supervised self-testing, received additional instructions on how to interpret the test results shown in six colour photos and filled out a questionnaire. Logistic regression and generalized estimating equations (GEE) were used in the statistical analysis. RESULTS: About 8.0% (95%CI:4.8%-11.2%) obtained an invalid self-test. An invalid result was inversely associated with male participants who had sex with men (OR=0.3;95%CI:0.1-1.0). Of the 3111 photos interpreted,4.9% (95%CI:4.1-5.7) were incorrect. Only 1.1% (95%CI:0.3-1.8) of the positive results were interpreted as negative. Age 30 or older (OR=2.1; 95%CI:1.2-3.7), having been born in Latin America (OR=1.6; 95%CI:1.1-2.2),and not having university education (OR=2.1;95%CI:1.2-3.7) were associated with misinterpreting test results in the GEE. Participant's perceptions of both their proficiency when conducting the test and interpretation were related with actual outcomes. Most participants (83.9%) were more motivated than before to use the self-test in the future, and 51.7% would pay >10 Euros for the test if it was sold in pharmacies. CONCLUSIONS: This is the first study showing that blood-based self-testing with current technology is feasible in HIV-negative participants demanding the test and without prior training or supervision. Bearing in mind that it was conducted under difficult weather conditions and using a complex kit, over-the-counter tests could be a feasible option to complement current diagnostic strategies. More studies are needed to accommodate technology, minimise interpretation mistakes and provide on-line support.
eng
Are participants in a street-based HIV testing program able to perform their own rapid test and interpret the results?
research article
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URL
https://repisalud.isciii.es/bitstreams/c4461de0-40d2-41c8-b608-57a04c707dcb/download
File
MD5
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application/pdf
AreParticipantsInA_2012.pdf
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https://repisalud.isciii.es/bitstreams/9afe5242-5bb2-4da5-88f6-3828460171e0/download
File
MD5
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text/plain
AreParticipantsInA_2012.pdf.txt