2026-04-29T12:23:10Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/67142025-06-12T14:03:03Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19611
Repisalud
author
Charle-Cuellar, Pilar
author
Berzosa, Pedro
author
Descalzo, Miguel Angel
author
de Lucio, Aida
author
Raso, Jose
author
Obono, Jacqueline
author
Lwanga, Magdalena
author
Nlang, Natividad
author
Nchama, Araceli
author
Mangue, Catalina
author
Micha, Anastasio
author
Nsee, Natividad
author
Mesie, Rosario
author
Benito, Agustin
author
Roche, Jesus
funder
Agencia Española de Cooperación Internacional para el Desarrollo
funder
Ministerio de Ciencia e Innovación (España)
funder
Instituto de Salud Carlos III
funder
RETICS-Investigación colaborativa en Enfermedades Tropicales (RICET-ISCIII) (España)
2018-11-23T12:24:56Z
2018-11-23T12:24:56Z
2009-05-27
J Trop Med. 2009;2009:781865.
10.1155/2009/781865
1687-9694
1687-9686
Journal of tropical medicine
20339460
http://hdl.handle.net/20.500.12105/6714
Objectives. The objectives of the study were (i) to evaluate the efficacy of combination drugs, such as artesunate + sulphadoxine-pyrimethamine (AS + SP) and amodiaquine + sulphadoxine-pyripethamine (AQ + SP) in treatment of uncomplicated falciparum malaria (ii) to differentiate recrudescence from reinfection by analysing msp-1 and msp-2 genes of Plasmodium falciparum in treatment failure cases. Methods. We carried out an in vivo study in the year 2005 in 206 children between 6 to 59 months age groups. Of the 206, 120 received AQ + SP, and 86 received AS + SP. A clinical and parasitological followup during 14 days was undertaken. Finger-prick blood sample from each patient was taken on Whatman filter paper (no. 3) on days 0, 7, 14 and also the day when the parasite and symptoms reappeared for PCR analysis. Results. Late treatment failure was observed in 3.5% (4/114) with AQ + SP, and 2.5% (2/79) with AS + SP. The success rate was 96.5% with AQ + SP and 97.5% with AS + SP. No deaths and severe reactions were recorded. Out of the 6 treatment failure cases, one was reinfection as observed by PCR analysis of msp-1 and msp-2 genes on day 14. Discussion. Both the combinations found to be efficacious and safe and could be used as a first-line treatment for uncomplicated falciparum malaria in Equatorial Guinea.
eng
Efficacy of Artesunate + Sulphadoxine-Pyrimethamine (AS + SP) and Amodiaquine + Sulphadoxine-Pyrimethamine (AQ + SP) for Uncomplicated falciparum Malaria in Equatorial Guinea (Central Africa)
research article
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URL
https://repisalud.isciii.es/bitstreams/9903d18b-b113-4296-a362-30ce1cad4e11/download
File
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application/pdf
EfficacyOfArtesunateSulphadoxine_2009.pdf
URL
https://repisalud.isciii.es/bitstreams/f584da7a-be9a-43db-922d-b83f29d077ea/download
File
MD5
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text/plain
EfficacyOfArtesunateSulphadoxine_2009.pdf.txt