2026-06-14T10:37:31Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/67082024-09-27T22:50:39Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Akuffo, Hannah
author
Costa, Carlos
author
van Griensven, Johan
author
Burza, Sakib
author
Moreno, Javier
author
Herrero, Mercè
2018-11-23T11:52:27Z
2018-11-23T11:52:27Z
2018-05-10
PLoS Negl Trop Dis. 2018 May 10;12(5):e0006375
10.1371/journal.pntd.0006375
1935-2735
1935-2735
PLoS neglected tropical diseases
29746470
http://hdl.handle.net/20.500.12105/6708
Immunosuppression contributes significantly to the caseload of visceral leishmaniasis (VL). HIV coinfection, solid organ transplantation, malnutrition, and helminth infections are the most important immunosuppression-related factors. This review briefly describes the challenges of these associations. East Africa and the Indian subcontinent are the places where HIV imposes the highest burden in VL. In the highlands of Northern Ethiopia, migrant rural workers are at a greater risk of coinfection and malnutrition, while in India, HIV reduces the sustainability of a successful elimination programme. As shown from a longitudinal cohort in Madrid, VL is an additional threat to solid organ transplantation. The association with malnutrition is more complex since it can be both a cause and a consequence of VL. Different regimes for therapy and secondary prevention are discussed as well as the role of nutrients on the prophylaxis of VL in poverty-stricken endemic areas.
eng
New insights into leishmaniasis in the immunosuppressed
journal article
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URL
https://repisalud.isciii.es/bitstreams/44a4ae81-0fda-423b-80c1-7b1a5b675e30/download
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NewInsightsIntoLeishmaniasis_2018.pdf
URL
https://repisalud.isciii.es/bitstreams/5ef0e4fa-1fd7-489b-a5ac-eed3f64b8829/download
File
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NewInsightsIntoLeishmaniasis_2018.pdf.txt