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oai:repisalud.isciii.es:20.500.12105/67082024-09-27T22:50:39Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Akuffo, Hannah author Costa, Carlos author van Griensven, Johan author Burza, Sakib author Moreno, Javier author Herrero, Mercè author 2018-05-10 Immunosuppression contributes significantly to the caseload of visceral leishmaniasis (VL). HIV coinfection, solid organ transplantation, malnutrition, and helminth infections are the most important immunosuppression-related factors. This review briefly describes the challenges of these associations. East Africa and the Indian subcontinent are the places where HIV imposes the highest burden in VL. In the highlands of Northern Ethiopia, migrant rural workers are at a greater risk of coinfection and malnutrition, while in India, HIV reduces the sustainability of a successful elimination programme. As shown from a longitudinal cohort in Madrid, VL is an additional threat to solid organ transplantation. The association with malnutrition is more complex since it can be both a cause and a consequence of VL. Different regimes for therapy and secondary prevention are discussed as well as the role of nutrients on the prophylaxis of VL in poverty-stricken endemic areas. PLoS Negl Trop Dis. 2018 May 10;12(5):e0006375 10.1371/journal.pntd.0006375 1935-2735 1935-2735 PLoS neglected tropical diseases 29746470 http://hdl.handle.net/20.500.12105/6708 New insights into leishmaniasis in the immunosuppressed