2026-04-27T01:59:19Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/66962024-09-27T10:04:46Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19607
Repisalud
author
Casquero-Veiga, Marta
author
García-García, David
author
Desco, Manuel
author
Luisa Soto-Montenegro, Maria
funder
Fundación Mapfre
funder
Centro de Investigación Biomedica en Red - CIBER
funder
Ministerio de Economía y Competitividad (España)
funder
Plan Nacional de Drogas (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Comunidad de Madrid (España)
funder
Fundación Alicia Koplowitz
funder
Instituto de Salud Carlos III
2018-11-22T08:10:54Z
2018-11-22T08:10:54Z
2018
Biomed Res Int. 2018; 2018:8560232
2314-6133
http://hdl.handle.net/20.500.12105/6696
30417016
10.1155/2018/8560232
2314-6141
BIOMED RESEARCH INTERNATIONAL
Deep brain stimulation (DBS) is a neurosurgery technique widely used in movement disorders, although its mechanism of action remains unclear. In fact, apart from the stimulation itself, the mechanical insertion of the electrode may play a crucial role. Here we aimed to distinguish between the insertional and the DBS effects on brain glucose metabolism. To this end, electrodes were implanted targeting the medial prefrontal cortex in five adult male Wistar rats. Positron Emission Tomography (PET) studies were performed before surgery (D0) and seven (D7) and nine days (D9) after that. DBS was applied during the (18)FDG uptake of the D9 study. PET data were analysed with statistical parametric mapping. We found an electrode insertional effect in cortical areas, while DBS resulted in a more widespread metabolic pattern. The consequences of simultaneous electrode and DBS factors revealed a combination of both effects. Therefore, the insertion metabolic effects differed from the stimulation ones, which should be considered when assessing DBS protocols.
eng
Understanding Deep Brain Stimulation: In Vivo Metabolic Consequences of the Electrode Insertional Effect
journal article
URL
https://repisalud.isciii.es/bitstreams/062cb152-9c89-4621-aed2-1b68e1f62edf/download
File
MD5
24148ce2c45dd47c7729d2a5311019e8
2612444
application/pdf
UnderstandingDeepBrainStimulation_2018.pdf
URL
https://repisalud.isciii.es/bitstreams/e1bfaf82-7b57-497a-be06-6cf84a4a2246/download
File
MD5
36d0169d118dc2462326a3cc2d39c90e
25330
text/plain
UnderstandingDeepBrainStimulation_2018.pdf.txt