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oai:repisalud.isciii.es:20.500.12105/66962024-09-27T10:04:46Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19607

00925njm 22002777a 4500 dc Casquero-Veiga, Marta author García-García, David author Desco, Manuel author Luisa Soto-Montenegro, Maria author 2018 Deep brain stimulation (DBS) is a neurosurgery technique widely used in movement disorders, although its mechanism of action remains unclear. In fact, apart from the stimulation itself, the mechanical insertion of the electrode may play a crucial role. Here we aimed to distinguish between the insertional and the DBS effects on brain glucose metabolism. To this end, electrodes were implanted targeting the medial prefrontal cortex in five adult male Wistar rats. Positron Emission Tomography (PET) studies were performed before surgery (D0) and seven (D7) and nine days (D9) after that. DBS was applied during the (18)FDG uptake of the D9 study. PET data were analysed with statistical parametric mapping. We found an electrode insertional effect in cortical areas, while DBS resulted in a more widespread metabolic pattern. The consequences of simultaneous electrode and DBS factors revealed a combination of both effects. Therefore, the insertion metabolic effects differed from the stimulation ones, which should be considered when assessing DBS protocols. Biomed Res Int. 2018; 2018:8560232 2314-6133 http://hdl.handle.net/20.500.12105/6696 30417016 10.1155/2018/8560232 2314-6141 BIOMED RESEARCH INTERNATIONAL Understanding Deep Brain Stimulation: In Vivo Metabolic Consequences of the Electrode Insertional Effect