2026-06-14T05:05:34Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/66932024-10-31T11:42:02Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Sanchez-Iranzo, Hector
author
Galardi-Castilla, Maria
author
Minguillon, Carolina
author
Sanz-Morejon, Andres
author
Gonzalez-Rosa, Juan Manuel
author
Felker, Anastasia
author
Ernst, Alexander
author
Guzman-Martinez, Gabriela
author
Mosimann, Christian
author
Mercader, Nadia
funder
Ministerio de Economía, Industria y Competitividad (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Swiss National Science Foundation
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Unión Europea. Comisión Europea
funder
Fundación ProCNIC
funder
Swiss Heart Foundation
2018-11-22T08:10:54Z
2018-11-22T08:10:54Z
2018
Nat Commun. 2018; 9(1):428
10.1038/s41467-017-02650-6
2041-1723
Nature Communications
29382818
http://hdl.handle.net/20.500.12105/6693
During development, mesodermal progenitors from the first heart field (FHF) form a primitive cardiac tube, to which progenitors from the second heart field (SHF) are added. The contribution of FHF and SHF progenitors to the adult zebrafish heart has not been studied to date. Here we find, using genetic tbx5a lineage tracing tools, that the ventricular myocardium in the adult zebrafish is mainly derived from tbx5a(+) cells, with a small contribution from tbx5a(+) SHF progenitors. Notably, ablation of ventricular tbx5a(+)-derived cardiomyocytes in the embryo is compensated by expansion of SHF-derived cells. In the adult, tbx5a expression is restricted to the trabeculae and excluded from the outer cortical layer. tbx5a-lineage tracing revealed that trabecular cardiomyocytes can switch their fate and differentiate into cortical myocardium during adult heart regeneration. We conclude that a high degree of cardiomyocyte cell fate plasticity contributes to efficient regeneration.
eng
Tbx5a lineage tracing shows cardiomyocyte plasticity during zebrafish heart regeneration
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