2026-06-14T03:31:53Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/66892024-09-27T09:45:24Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
van Dinther, Dieke
author
Veninga, Henrike
author
Iborra, Salvador
author
Borg, Ellen G. F.
author
Hoogterp, Leoni
author
Olesek, Katarzyna
author
Beijer, Marieke R.
author
Schetters, Sjoerd T. T.
author
Kalay, Hakan
author
Garcia-Vallejo, Juan J.
author
Franken, Kees L.
author
Cham, Lamin B.
author
Lang, Karl S.
author
van Kooyk, Yvette
author
Sancho, David
author
Crocker, Paul R.
author
den Haan, Joke M. M.
funder
National Institutes of Health (Estados Unidos)
funder
Centro Nacional de Investigaciones Cardiovasculares Carlos III (España)
funder
Ministerio de Economía, Industria y Competitividad (España)
funder
Agencia Estatal de Investigación (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Fondation ACTERIA (Acting on European Research in Immunology and Allergology)
funder
Unión Europea. Comisión Europea
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Dutch Cancer Society (Holanda)
2018-11-22T08:10:53Z
2018-11-22T08:10:53Z
2018
Cell Rep. 2018; 22(6):1484-1495
10.1016/j.celrep.2018.01.021
2211-1247
Cell Reports
29425504
http://hdl.handle.net/20.500.12105/6689
Splenic CD169(+) macrophages are located in the marginal zone to efficiently capture blood-borne pathogens. Here, we investigate the requirements for the induction of CD8(+) T cell responses by antigens (Ags) bound by CD169(+) macrophages. Upon Ag targeting to CD169(+) macrophages, we show that BATF3-dependent CD8 alpha(+) dendritic cells (DCs) are crucial for DNGR-1-mediated cross-priming of CD8(+) T cell responses. In addition, we demonstrate that CD169, a sialic acid binding lectin involved in cell-cell contact, preferentially binds to CD8 alpha(+) DCs and that Ag transfer to CD8 alpha(+) DCs and subsequent T cell activation is dependent on the sialic acid-binding capacity of CD169. Finally, functional CD169 mediates optimal CD8(+) T cell responses to modified vaccinia Ankara virus infection. Together, these data indicate that the collaboration of CD169(+) macrophages and CD8 alpha(+) DCs for the initiation of effective CD8(+) T cell responses is facilitated by binding of CD169 to sialic acid containing ligands on CD8 alpha(+) DCs.
eng
Functional CD169 on Macrophages Mediates Interaction with Dendritic Cells for CD8(+) T Cell Cross-Priming
journal article
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FunctionalCD169OnMacrophages_2018.pdf
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FunctionalCD169OnMacrophages_2018-mmc1.pdf
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FunctionalCD169OnMacrophages_2018.pdf.txt
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