2026-04-29T07:21:36Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/66852024-10-31T11:57:49Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Martinez-Mateu, Laura
author
Romero, Lucia
author
Ferrer-Albero, Ana
author
Sebastian, Rafael
author
Rodriguez Matas, Jose F.
author
Jalife, Jose
author
Berenfeld, Omer
author
Saiz, Javier
funder
Generalitat Valenciana (España)
funder
Ministerio de Economía, Industria y Competitividad (España)
funder
Unión Europea. Comisión Europea
funder
Ministerio de Economía y Competitividad (España)
funder
Agencia Estatal de Investigación (España)
funder
National Institutes of Health (Estados Unidos)
funder
Medtronic
funder
European Regional Development Fund
2018-11-22T08:10:53Z
2018-11-22T08:10:53Z
2018
PLoS Comput Biol. 2018; 14(3):e1006017
1553-7358
http://hdl.handle.net/20.500.12105/6685
29505583
10.1371/journal.pcbi.1006017
PLoS Computational Biology
Anatomically based procedures to ablate atrial fibrillation (AF) are often successful in terminating paroxysmal AF. However, the ability to terminate persistent AF remains disappointing. New mechanistic approaches use multiple-electrode basket catheter mapping to localize and target AF drivers in the form of rotors but significant concerns remain about their accuracy. We aimed to evaluate how electrode-endocardium distance, far-field sources and inter-electrode distance affect the accuracy of localizing rotors. Sustained rotor activation of the atria was simulated numerically and mapped using a virtual basket catheter with varying electrode densities placed at different positions within the atrial cavity. Unipolar electrograms were calculated on the entire endocardial surface and at each of the electrodes. Rotors were tracked on the interpolated basket phase maps and compared with the respective atrial voltage and endocardial phase maps, which served as references. Rotor detection by the basket maps varied between 35-94\% of the simulation time, depending on the basket's position and the electrode-to-endocardial wall distance. However, two different types of phantom rotors appeared also on the basket maps. The first type was due to the far-field sources and the second type was due to interpolation between the electrodes; increasing electrode density decreased the incidence of the second but not the first type of phantom rotors. In the simulations study, basket catheter-based phase mapping detected rotors even when the basket was not in full contact with the endocardial wall, but always generated a number of phantom rotors in the presence of only a single real rotor, which would be the desired ablation target. Phantom rotors may mislead and contribute to failure in AF ablation procedures.
eng
Factors affecting basket catheter detection of real and phantom rotors in the atria: A computational study
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