2026-05-16T22:07:42Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/66742024-11-28T16:09:28Zcom_20.500.12105_19604com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19605col_20.500.12105_16938
Repisalud
author
del Fresno, Carlos
author
Iborra, Salvador
author
Saz-Leal, Paula
author
Martinez-Lopez, Maria
author
Sancho, David
funder
Asociación Española Contra el Cáncer
funder
Ministerio de Economía, Industria y Competitividad (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Educación (España)
funder
Centro Nacional de Investigaciones Cardiovasculares Carlos III (España)
funder
Comunidad de Madrid (España)
funder
Instituto de Salud Carlos III
funder
Fondation ACTERIA (Acting on European Research in Immunology and Allergology)
funder
Atresmedia
funder
Fundación La Marató TV3
funder
Unión Europea. Comisión Europea
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Fundación ProCNIC
funder
Unión Europea. Comisión Europea. H2020
2018-11-22T08:10:51Z
2018-11-22T08:10:51Z
2018
Front Immunol. 2018; 9:804
10.3389/fimmu.2018.00804
1664-3224
Frontiers in Immunology
29755458
http://hdl.handle.net/20.500.12105/6674
Myeloid C-type lectin receptors (CLRs) are important sensors of self and non-self that work in concert with other pattern recognition receptors (PRRs). CLRs have been previously classified based on their signaling motifs as activating or inhibitory receptors. However, specific features of the ligand binding process may result in distinct signaling through a single motif, resulting in the triggering of non-canonical pathways. In addition, CLR ligands are frequently exposed in complex structures that simultaneously bind different CLRs and other PRRs, which lead to integration of heterologous signaling among diverse receptors. Herein, we will review how sensing by myeloid CLRs and crosstalk with heterologous receptors is modulated by many factors affecting their signaling and resulting in differential outcomes for immunity and inflammation. Finding common features among those flexible responses initiated by diverse CLR-ligand partners will help to harness CLR function in immunity and inflammation.
eng
Lectin receptors
Signaling
Monocytes
Macrophages
Dendritic cells
Innate immunity
Inflammation
PATTERN-RECOGNITION RECEPTOR
MYCOBACTERIAL CORD FACTOR
DENDRITIC CELL IMMUNORECEPTOR
INNATE ANTIFUNGAL IMMUNITY
BETA-GLUCAN RECEPTOR
TOLL-LIKE RECEPTOR-2
SYK TYROSINE KINASE
CANDIDA-ALBICANS
DC-SIGN
HOST-DEFENSE
Flexible Signaling of Myeloid C-Type Lectin Receptors in Immunity and Inflammation
journal article
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https://repisalud.isciii.es/bitstreams/ce8431e9-8a70-45fb-bf01-190dfac47397/download
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FlexibleSignalingOfMyeloid_2018.pdf
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File
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b3cd4dc23d61e21e07f7eeaa87ab786f
82016
text/plain
FlexibleSignalingOfMyeloid_2018.pdf.txt