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00925njm 22002777a 4500 dc del Fresno, Carlos author Iborra, Salvador author Saz-Leal, Paula author Martinez-Lopez, Maria author Sancho, David author 2018 Myeloid C-type lectin receptors (CLRs) are important sensors of self and non-self that work in concert with other pattern recognition receptors (PRRs). CLRs have been previously classified based on their signaling motifs as activating or inhibitory receptors. However, specific features of the ligand binding process may result in distinct signaling through a single motif, resulting in the triggering of non-canonical pathways. In addition, CLR ligands are frequently exposed in complex structures that simultaneously bind different CLRs and other PRRs, which lead to integration of heterologous signaling among diverse receptors. Herein, we will review how sensing by myeloid CLRs and crosstalk with heterologous receptors is modulated by many factors affecting their signaling and resulting in differential outcomes for immunity and inflammation. Finding common features among those flexible responses initiated by diverse CLR-ligand partners will help to harness CLR function in immunity and inflammation. Front Immunol. 2018; 9:804 10.3389/fimmu.2018.00804 1664-3224 Frontiers in Immunology 29755458 http://hdl.handle.net/20.500.12105/6674 Lectin receptors Signaling Monocytes Macrophages Dendritic cells Innate immunity Inflammation PATTERN-RECOGNITION RECEPTOR MYCOBACTERIAL CORD FACTOR DENDRITIC CELL IMMUNORECEPTOR INNATE ANTIFUNGAL IMMUNITY BETA-GLUCAN RECEPTOR TOLL-LIKE RECEPTOR-2 SYK TYROSINE KINASE CANDIDA-ALBICANS DC-SIGN HOST-DEFENSE Flexible Signaling of Myeloid C-Type Lectin Receptors in Immunity and Inflammation