2026-07-21T14:26:58Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/66722024-11-28T16:28:38Zcom_20.500.12105_19604com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19605col_20.500.12105_16938
Repisalud
author
Martinez-Lopez, Maria
author
Soto, Manuel
author
Iborra, Salvador
author
Sancho, David
funder
Ministerio de Economía, Industria y Competitividad (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Educación, Cultura y Deporte (España)
funder
Centro Nacional de Investigaciones Cardiovasculares Carlos III (España)
funder
Agencia Estatal de Investigación (España)
funder
Comunidad de Madrid (España)
funder
Instituto de Salud Carlos III
funder
Fondation ACTERIA (Acting on European Research in Immunology and Allergology)
funder
Atresmedia
funder
Fundación La Marató TV3
funder
Unión Europea. Comisión Europea
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Fundación ProCNIC
2018-11-22T08:10:51Z
2018-11-22T08:10:51Z
2018
Front Microbiol. 2018; 9:883
10.3389/fmicb.2018.00883
1664-302X
FRONTIERS IN MICROBIOLOGY
29867798
http://hdl.handle.net/20.500.12105/6672
Protozoan parasites of the Leishmania genus are the causative agents of leishmaniasis, a group of neglected tropical diseases whose clinical manifestations vary depending on the infectious Leishmania species but also on host factors. Recognition of the parasite by host myeloid immune cells is a key to trigger an effective Leishmania-specific immunity. However, the parasite is able to persist in host myeloid cells by evading, delaying and manipulating host immunity in order to escape host resistance and ensure its transmission. Neutrophils are first in infiltrating infection sites and could act either favoring or protecting against infection, depending on factors such as the genetic background of the host or the parasite species. Macrophages are the main host cells where the parasites grow and divide. However, macrophages are also the main effector population involved in parasite clearance. Parasite elimination by macrophages requires the priming and development of an effector Th1 adaptive immunity driven by specific subtypes of dendritic cells. Herein, we will provide a comprehensive outline of how myeloid cells regulate innate and adaptive immunity against Leishmania, and the mechanisms used by the parasites to promote their evasion and sabotage. Understanding the interactions between Leishmania and the host myeloid cells may lead to the development of new therapeutic approaches and improved vaccination to leishmaniases, an important worldwide health problem in which current therapeutic or preventive approaches are limited.
eng
Myeloid cell
Leishmania
Immune escape
Neutrophils
Macrophages
Dendritic cells
NEUTROPHIL EXTRACELLULAR TRAPS
CD8(+) T-CELLS
MACROPHAGE IL-12 PRODUCTION
TYROSINE-PHOSPHATASE SHP-1
NITRIC-OXIDE SYNTHASE
HUMAN DENDRITIC CELLS
PROTEIN-KINASE-C
KINETOPLASTID MEMBRANE PROTEIN-11
DONOVANI PROMASTIGOTES EVADE
SUSCEPTIBLE BALB/C MICE
Leishmania Hijacks Myeloid Cells for Immune Escape
journal article
URL
https://repisalud.isciii.es/bitstreams/83ad0129-a824-46b5-bf0c-0cfd0b28e73c/download
File
MD5
533055dbcfe8ab7c5811bd094d164f00
2547803
application/pdf
LeishmaniaHijacksMyeloidCells_2018.pdf
URL
https://repisalud.isciii.es/bitstreams/7f60f13e-e048-4e7e-b867-18e7034ff6a0/download
File
MD5
43554ef0fee2b99be52d0ee6cb4b8ae8
109271
text/plain
LeishmaniaHijacksMyeloidCells_2018.pdf.txt