2026-08-05T15:04:29Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/66672024-09-27T08:35:47Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Saiz, Maria Laura
author
Rocha-Perugini, Vera
author
Sanchez-Madrid, Francisco
funder
European Regional Development Fund
funder
Ministerio de Economía, Innovación y Competitividad (España)
funder
Fundación ProCNIC
funder
Centro de Investigación Biomedica en Red - CIBER
funder
Unión Europea. Comisión Europea
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
2018-11-22T08:10:50Z
2018-11-22T08:10:50Z
2018
Front Immunol. 2018; 9:1074
10.3389/fimmu.2018.01074
1664-3224
Frontiers in Immunology
29875769
http://hdl.handle.net/20.500.12105/6667
Professional antigen-presenting cells (APCs) include dendritic cells, monocytes, and B cells. APCs internalize and process antigens, producing immunogenic peptides that enable antigen presentation to T lymphocytes, which provide the signals that trigger T-cell activation, proliferation, and differentiation, and lead to adaptive immune responses. After detection of microbial antigens through pattern recognition receptors (PRRs), APCs migrate to secondary lymphoid organs where antigen presentation to T lymphocytes takes place. Tetraspanins are membrane proteins that organize specialized membrane platforms, called tetraspanin-enriched microdomains, which integrate membrane receptors, like PRR and major histocompatibility complex class II (MHC-II), adhesion proteins, and signaling molecules. Importantly, through the modulation of the function of their associated membrane partners, tetraspanins regulate different steps of the immune response. Several tetraspanins can positively or negatively regulate the activation threshold of immune receptors. They also play a role during migration of APCs by controlling the surface levels and spatial arrangement of adhesion molecules and their subsequent intracellular signaling. Finally, tetraspanins participate in antigen processing and are important for priming of naive T cells through the control of T-cell co-stimulation and MHC-II-dependent antigen presentation. In this review, we discuss the role of tetraspanins in APC biology and their involvement in effective immune responses.
eng
Tetraspanins
Tetraspanin-enriched microdomains
Antigen-presenting cells
Immune receptors
Cell migration
Antigen presentation
MHC CLASS-II
PLASMACYTOID DENDRITIC CELLS
HEPATITIS-C VIRUS
T-CELLS
MOLECULAR CHARACTERIZATION
MEMBRANE MICRODOMAIN
SIGNALING COMPLEXES
PEPTIDE COMPLEXES
DISTINCT SUBSET
DOWN-REGULATION
Tetraspanins as Organizers of Antigen-Presenting Cell Function
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