2026-08-05T15:43:09Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/66662024-09-27T09:11:49Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Salinas-Munoz, Laura
author
Campos-Fernandez, Raul
author
Mercader, Enrique
author
Olivera-Valle, Irene
author
Fernandez-Pacheco, Carlota
author
Matilla, Lara
author
Garcia-Bordas, Julio
author
Brazil, Jennifer C.
author
Parkos, Charles A.
author
Asensio, Fernando
author
Munoz-Fernandez, Maria A.
author
Hidalgo, Andres
author
Sanchez-Mateos, Paloma
author
Samaniego, Rafael
author
Relloso, Miguel
funder
Fundación Mutua Madrileña
funder
Ministerio de Economía y Competitividad (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Instituto de Salud Carlos III
2018-11-22T08:10:50Z
2018-11-22T08:10:50Z
2018
Front Immunol. 2018; 9:1033
10.3389/fimmu.2018.01033
1664-3224
Frontiers in Immunology
29881378
http://hdl.handle.net/20.500.12105/6666
Estradiol-based therapies predispose women to vaginal infections. Moreover, it has long been known that neutrophils are absent from the vaginal lumen during the ovulatory phase (high estradiol). However, the mechanisms that regulate neutrophil influx to the vagina remain unknown. We investigated the neutrophil transepithelial migration (TEM) into the vaginal lumen. We revealed that estradiol reduces the CD44 and CD47 epithelial expression in the vaginal ectocervix and fornix, which retain neutrophils at the apical epithelium through the estradiol receptor-alpha. In contrast, luteal progesterone increases epithelial expression of CD44 and CD47 to promote neutrophil migration into the vaginal lumen and Candida albicans destruction. Distinctive to vaginal mucosa, neutrophil infiltration is contingent to sex hormones to prevent sperm from neutrophil attack; although it may compromise immunity during ovulation. Thus, sex hormones orchestrate tolerance and immunity in the vaginal lumen by regulating neutrophil TEM.
eng
Estradiol
ESR1
Progesterone
Neutrophils
Transepithelial migration
Cervix
NEUTROPHIL-EPITHELIAL INTERACTIONS
TRANSEPITHELIAL MIGRATION
SEX-HORMONES
INTESTINAL EPITHELIUM
CHEMOKINE GRADIENTS
VAGINA
TRANSMIGRATION
IMMUNITY
CELLS
INFILTRATION
Estrogen Receptor-Alpha (ESR1) Governs the Lower Female Reproductive Tract Vulnerability to Candida albicans
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