2026-06-14T03:33:48Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/66622025-04-30T11:20:44Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_19604col_20.500.12105_16977col_20.500.12105_19607
Repisalud
author
GarcÍa, Marcial
author
Navarrete-Muñoz, Maria Angeles
author
Ligos, Jose M.
author
Cabello, Alfonso
author
Restrepo, Clara
author
Lopez-Bernaldo, Juan Carlos
author
de la Hera, Francisco Javier
author
Barros, Carlos
author
Montoya, Maria
author
Fernandez-Guerrero, Manuel
author
Estrada, Vicente
author
Gorgolas, Miguel
author
Benito, José Miguel
author
Rallon, Norma
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Instituto de Salud Carlos III
funder
Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
2018-11-22T08:10:49Z
2018-11-22T08:10:49Z
2018
Sci Rep. 2018; 8(1):15541
10.1038/s41598-018-33749-5
2045-2322
Scientific Reports
30341387
http://hdl.handle.net/20.500.12105/6662
A recent study has pointed out to CD32a as a potential biomarker of HIV-persistent CD4 cells. We have characterized the level and phenotype of CD32+ cells contained in different subsets of CD4 T-cells and its potential correlation with level of total HIV-DNA in thirty HIV patients (10 typical progressors naive for cART, 10 cART-suppressed patients, and 10 elite controllers). Total HIV-DNA was quantified in different subsets of CD4 T-cells: Trm and pTfh cells. Level and immunephenotype of CD32+ cells were analyzed in these same subsets by flow cytometry. CD32 expression in Trm and pTfh subsets was similar in the different groups, and there was no significant correlation between the level of total HIV-DNA and the level of CD32 expression in these subsets. However, total HIV-DNA level was correlated with expression of CD127 (rho = -0.46, p = 0.043) and of CCR6 (rho = -0.418, p = 0.027) on CD32+ cells. Our results do not support CD32 as a biomarker of total HIV-DNA content. However, analyzing the expression of certain markers by CD32+ cells could improve the utility of this marker in the clinical setting, prompting the necessity of further studies to both validate our results and to explore the potential utility of certain markers expressed by CD32+ cells.
eng
ACTIVE ANTIRETROVIRAL THERAPY
HUMAN T-CELLS
LATENT RESERVOIR
INFECTED INDIVIDUALS
TH17 CELLS
PERSISTENCE
RECEPTORS
BLOOD
SUBPOPULATIONS
LYMPHOCYTES
CD32 Expression is not Associated to HIV-DNA content in CD4 cell subsets of individuals with Different Levels of HIV Control
journal article
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9efd387fe7f69280f16216579dbe799d
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CD32ExpressionIsNotAssociated_2018.pdf
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https://repisalud.isciii.es/bitstreams/601a3e98-cfe4-4e69-85ad-ffbce06d2be1/download
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060f4b3388b22b876167621e17aa5b97
46452
text/plain
CD32ExpressionIsNotAssociated_2018.pdf.txt