2026-06-14T03:40:41Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/66542025-04-24T17:23:48Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_16959col_20.500.12105_16962col_20.500.12105_16964col_20.500.12105_16970col_20.500.12105_16974col_20.500.12105_16981col_20.500.12105_16983

00925njm 22002777a 4500 dc Ibáñez-Sanz, Gemma author Díez-Villanueva, Anna author Alonso, María Henar author Rodríguez-Moranta, Francisco author Perez-Gomez, Beatriz author Bustamante, Mariona author Martín, Vicente author Llorca, Javier author Amiano, Pilar author Ardanaz, Eva author Tardón, Adonina author Jimenez-Moleon, Jose J. author Peiró, Rosana author Alguacil, Juan author Navarro Rivas, Carmen author Guinó, Elisabet author Binefa, Gemma author Fernandez-Navarro, Pablo L author Espinosa, Anna author Dávila-Batista, Verónica author Molina, Antonio José author Palazuelos, Camilo author Castaño-Vinyals, Gemma author Aragones, Nuria author Kogevinas, Manolis author Moreno, Victor author Pollan-Santamaria, Marina author 2017-02-24 Colorectal cancer (CRC) screening of the average risk population is only indicated according to age. We aim to elaborate a model to stratify the risk of CRC by incorporating environmental data and single nucleotide polymorphisms (SNP). The MCC-Spain case-control study included 1336 CRC cases and 2744 controls. Subjects were interviewed on lifestyle factors, family and medical history. Twenty-one CRC susceptibility SNPs were genotyped. The environmental risk model, which included alcohol consumption, obesity, physical activity, red meat and vegetable consumption, and nonsteroidal anti-inflammatory drug use, contributed to CRC with an average per factor OR of 1.36 (95% CI 1.27 to 1.45). Family history of CRC contributed an OR of 2.25 (95% CI 1.87 to 2.72), and each additional SNP contributed an OR of 1.07 (95% CI 1.04 to 1.10). The risk of subjects with more than 25 risk alleles (5th quintile) was 82% higher (OR 1.82, 95% CI 1.11 to 2.98) than subjects with less than 19 alleles (1st quintile). This risk model, with an AUROC curve of 0.63 (95% CI 0.60 to 0.66), could be useful to stratify individuals. Environmental factors had more weight than the genetic score, which should be considered to encourage patients to achieve a healthier lifestyle. Sci Rep. 2017 Feb 24:7:43263. 10.1038/srep43263 2045-2322 2045-2322 Scientific Reports 28233817 http://hdl.handle.net/20.500.12105/6654 Risk Model for Colorectal Cancer in Spanish Population Using Environmental and Genetic Factors: Results from the MCC-Spain study