2026-08-05T11:45:36Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/66502024-09-27T08:57:35Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605col_20.500.12105_19607
Repisalud
author
Otero-Ortega, Laura
author
Gómez de Frutos, Mari Carmen
author
Laso-García, Fernando
author
Rodríguez-Frutos, Berta
author
Medina-Gutiérrez, Esperanza
author
Lopez, Juan Antonio
author
Vazquez, Jesus
author
Díez-Tejedor, Exuperio
author
Gutiérrez-Fernández, María
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Ciencia e Innovación (España)
funder
Instituto de Salud Carlos III
2018-11-20T14:46:25Z
2018-11-20T14:46:25Z
2018-05
J Cereb Blood Flow Metab. 2018; 38(5):767-79
10.1177/0271678X17708917
1559-7016
0271-678X
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
28524762
http://hdl.handle.net/20.500.12105/6650
Exosomes are gaining importance because they show great promise in therapeutic applications for several diseases. Particularly in stroke, exosomes derived from mesenchymal stem cell (MSC) therapy work as paracrine effectors responsible for promoting neurovascular remodeling and functional recovery. Adult male rats were subjected to intracerebral hemorrhage (ICH) by intrastriatal injection of collagenase type IV; 24 h after surgery, MSC-derived exosomes were administered through the tail vein. The rats were euthanized at 7 or 28 days after treatment. Functional evaluation, lesion size, fiber tract integrity, axonal sprouting and white matter repair markers, biodistribution of exosomes and secretome proteomics were analyzed. DiI-labeled exosomes were found in the brains of the ICH-treated group and in the liver, lung and spleen. Animals receiving treatment with exosomes showed significantly better results in terms of functional recovery, lesion size, fiber tract integrity, axonal sprouting and white matter repair markers compared with the control group 28 days after stroke. Proteomics analysis of the exosomes identified more than 2000 proteins that could be implicated in brain repair function. In conclusion, white matter integrity was partly restored by exosome administration mediated by molecular repair factors. Exosomes as a treatment could be a heterogeneous process by nature and presents many factors that can influence brain plasticity in an adaptable and versatile manner.
eng
Brain repair
Exosome
Intracerebral hemorrhage
Subcortical stroke
White matter injury
Exosomes promote restoration after an experimental animal model of intracerebral hemorrhage
journal article
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URL
https://repisalud.isciii.es/bitstreams/7ee07078-13c8-4f27-bdfb-163660a481cf/download
File
MD5
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application/pdf
Accepted_exosom.pdf
URL
https://repisalud.isciii.es/bitstreams/e29f10f5-800e-4876-8cd7-0769e83df0ee/download
File
MD5
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text/plain
Accepted_exosom.pdf.txt