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oai:repisalud.isciii.es:20.500.12105/66452025-03-26T11:31:45Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Broberg, Eeva K author Hungnes, Olav author Schweiger, Brunhilde author Prosenc, Katarina author Daniels, Rod author Guiomar, Raquel author Ikonen, Niina author Kossyvakis, Athanasios author Pozo Sanchez, Francisco author Puzelli, Simona author Thomas, Isabelle author Waters, Allison author Wiman, Åsa author Meijer, Adam author 2016-10-13 Influenza antigenic and genetic characterisation data are crucial for influenza vaccine composition decision making. Previously, aggregate data were reported to the European Centre for Disease Prevention and Control by European Union/European Economic Area (EU/EEA) countries. A system for collecting case-specific influenza antigenic and genetic characterisation data was established for the 2013/14 influenza season. In a pilot study, 11 EU/EEA countries reported through the new mechanism. We demonstrated feasibility of reporting strain-based antigenic and genetic data and ca 10% of influenza virus-positive specimens were selected for further characterisation. Proportions of characterised virus (sub)types were similar to influenza virus circulation levels. The main genetic clades were represented by A/StPetersburg/27/2011(H1N1)pdm09 and A/Texas/50/2012(H3N2). A(H1N1)pdm09 viruses were more prevalent in age groups (by years) < 1 (65%; p = 0.0111), 20-39 (50%; p = 0.0046) and 40-64 (55%; p = 0.00001) while A(H3N2) viruses were most prevalent in those ≥ 65 years (62%*; p = 0.0012). Hospitalised patients in the age groups 6-19 years (67%; p = 0.0494) and ≥ 65 years (52%; p = 0.0005) were more frequently infected by A/Texas/50/2012 A(H3N2)-like viruses compared with hospitalised cases in other age groups. Strain-based reporting enabled deeper understanding of influenza virus circulation among hospitalised patients and substantially improved the reporting of virus characterisation data. Therefore, strain-based reporting of readily available data is recommended to all reporting countries within the EU/EEA. Euro Surveill. 2016; 21(41) 10.2807/1560-7917.ES.2016.21.41.30370 1560-7917 1025-496X Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 27762211 http://hdl.handle.net/20.500.12105/6645 age genetic clade hospitalisation influenza influenza season Improving influenza virological surveillance in Europe: strain-based reporting of antigenic and genetic characterisation data, 11 European countries, influenza season 2013/14