2026-08-05T15:15:52Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/66232024-11-29T20:38:03Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Di Paolo, Virginia
author
Russo, Ida
author
Boldrini, Renata
author
Ravà, Lucilla
author
Pezzullo, Marco
author
Benedetti, Maria Chiara
author
Galardi, Angela
author
Colletti, Marta
author
Rota, Rossella
author
Orlando, Domenico
author
Crocoli, Alessandro
author
Peinado Selgas , Hector
author
Milano, Giuseppe Maria
author
Di Giannatale, Angela
2018-11-16T13:00:47Z
2018-11-16T13:00:47Z
2018
BMC Cancer.(2018); 18(1):31.
10.1186/s12885-017-3947-4
1471-2407
1471-2407
BMC cancer
29304781
http://hdl.handle.net/20.500.12105/6623
BACKGROUND: The Intratumoral Microvessel Density (IMVD) is commonly used to quantify tumoral vascularization and is usually assessed by pan-endothelial markers, such as CD31. Endoglin (CD105) is a protein predominantly expressed in proliferating endothelium and the IMVD determined by this marker measures specifically the neovascularization. In this study, we investigated the CD105 expression in pediatric rhabdomyosarcoma and assessed the neovascularization by using the angiogenic ratio IMVD-CD105 to IMVD-CD31. METHODS: Paraffin-embedded archival tumor specimens were selected from 65 pediatric patients affected by rhabdomyosarcoma. The expression levels of CD105, CD31 and Vascular Endothelial Growth Factor (VEGF) were investigated in 30 cases (18 embryonal and 12 alveolar) available for this study. The IMVD-CD105 to IMVD-CD31 expression ratio was correlated with clinical and pathologic features of these patients. RESULTS: We found a specific expression of endoglin (CD105) in endothelial cells of all the rhabdomyosarcoma specimens analyzed. We observed a significant positive correlation between the IMVD individually measured by CD105 and CD31. The CD105/CD31 expression ratio was significantly higher in patients with lower survival and embryonal histology. Indeed, patients with a CD105/CD31 expression ratio < 1.3 had a significantly increased OS (88%, 95%CI, 60%-97%) compared to patients with higher values (40%, 95%CI, 12%-67%). We did not find any statistical correlation among VEGF and EFS, OS and CD105/CD31 expression ratio. CONCLUSION: CD105 is expressed on endothelial cells of rhabdomyosarcoma and represent a useful tool to quantify neovascularization in this tumor. If confirmed by further studies, these results will indicate that CD105 is a potential target for combined therapies in rhabdomyosarcoma.
eng
CD105/CD31 ratio
Endoglin (CD105)
Prognostic marker
Rhabdomyosarcoma
Evaluation of Endoglin (CD105) expression in pediatric rhabdomyosarcoma
journal article
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EvaluationofEndoglin(CD105)_2018.pdf
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EvaluationofEndoglin(CD105)_2018.pdf.txt
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