2026-06-14T03:31:08Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/66212024-11-28T16:43:58Zcom_20.500.12105_2173com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19597col_20.500.12105_16958
Repisalud
author
Quintanal-Villalonga, Alvaro
author
Ojeda-Marquez, Laura
author
Marrugal, Ángela
author
Yagüe, Patricia
author
Ponce-Aix, Santiago
author
Salinas, Ana
author
Carnero, Amancio
author
Ferrer, Irene
author
Molina-Pinelo, Sonia
author
Paz Ares , Luis Gonzaga
funder
Instituto de Salud Carlos III
funder
Centro de Investigación Biomedica en Red - CIBER
funder
Fundación Mutua Madrileña
funder
Regional Government of Andalusia (España)
2018-11-16T12:35:58Z
2018-11-16T12:35:58Z
2018
Sci Rep. 2018; 8(1):2394.
10.1038/s41598-018-20570-3
2045-2322
2045-2322
Scientific reports
29402970
http://hdl.handle.net/20.500.12105/6621
The FGFR4-388Arg variant has been related to poor prognosis in several types of cancer, including lung cancer. The mechanism underlying this association has not been addressed in detail in patients with this pathology. Here, we report that this FGFR4 variant induces MAPK and STAT3 activation and causes pro-oncogenic effects in NSCLC in vitro and in vivo. This variant induces the expression of EMT-related genes, such as N-cadherin, vimentin, Snail1 and Twist1. Indeed, the induction of N-cadherin protein expression by this variant is essential for its pro-tumorigenic role. The presence of the FGFR4-388Arg variant correlates with higher N-cadherin expression levels in clinical NSCLC samples and with poorer outcome in patients with FGFR expression. These results support the prognostic role of this FGFR variant in lung cancer and show that these effects may be mediated by the induction of N-cadherin expression and an EMT phenotype.
eng
FACTOR RECEPTOR 4
EPITHELIAL-MESENCHYMAL TRANSITION;
FGFR4 GLY388ARG POLYMORPHISM
EXTRAHEPATIC CHOLANGIOCARCINOMA;
HEPATOCELLULAR-CARCINOMA;
PROGNOSTIC-SIGNIFICANCE
ARG(388) ALLELE
SURVIVAL
CELLS
STAT3
The FGFR4-388arg Variant Promotes Lung Cancer Progression by N-Cadherin Induction
journal article
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TheFGFR4-388argVariant_2018.pdf
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TheFGFR4-388argVariant_2018_MOESM1_ESM.pdf
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TheFGFR4-388argVariant_2018.pdf.txt
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TheFGFR4-388argVariant_2018_MOESM1_ESM.pdf.txt