2026-08-29T10:01:42Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/66102025-04-30T10:23:47Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19611
Repisalud
author
Cordon-Obras, Carlos
author
Garcia-Estebanez, Carmen
author
Ndong-Mabale, Nicolas
author
Abaga, Simón
author
Ndongo-Asumu, Pedro
author
Benito, Agustin
author
Ochando, Jordi
funder
Instituto de Salud Carlos III
funder
Agencia Española de Cooperación Internacional para el Desarrollo
2018-11-16T09:45:58Z
2018-11-16T09:45:58Z
2010-06-08
PLoS Negl Trop Dis. 2010;4(6):e704.
10.1371/journal.pntd.0000704
1935-2735
1935-2735
PLoS neglected tropical diseases
20544031
http://hdl.handle.net/20.500.12105/6610
BACKGROUND: Sleeping sickness is spread over 36 Sub-Saharan African countries. In West and Central Africa, the disease is caused by Trypanosoma brucei gambiense, which produces a chronic clinical manifestation. The Luba focus (Bioko Island, Equatorial Guinea) has not reported autochthonous sleeping sickness cases since 1995, but given the complexity of the epidemiological cycle, the elimination of the parasite in the environment is difficult to categorically ensure. METHODOLOGY/PRINCIPAL FINDINGS: The aim of this work is to assess, by a molecular approach (Polymerase Chain Reaction, PCR), the possible permanence of T. b. gambiense in the vector (Glossina spp.) and domestic fauna in order to improve our understanding of the epidemiological situation of the disease in an isolated focus considered to be under control. The results obtained show the absence of the parasite in peridomestic livestock but its presence, although at very low rate, in the vector. On the other hand, interesting entomological data highlight that an elevated concentration of tsetse flies was observed in two out of the ten villages considered to be in the focus. CONCLUSIONS: These findings demonstrate that even in conditions of apparent control, a complete parasite clearance is difficult to achieve. Further investigations must be focused on animal reservoirs which could allow the parasites to persist without leading to human cases. In Luba, where domestic livestock are scarcer than other foci in mainland Equatorial Guinea, the epidemiological significance of wild fauna should be assessed to establish their role in the maintenance of the infection.
eng
Screening of Trypanosoma brucei gambiense in domestic livestock and tsetse flies from an insular endemic focus (Luba, Equatorial Guinea)
research article
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URL
https://repisalud.isciii.es/bitstreams/9c3d5b76-bfad-4fb6-97f5-0d96d1630d35/download
File
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application/pdf
ScreeningOfTrypanosomaBrucei_2010.pdf
URL
https://repisalud.isciii.es/bitstreams/459f4229-1419-42a9-9753-beb8682d83e6/download
File
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text/plain
ScreeningOfTrypanosomaBrucei_2010.pdf.txt