2026-04-29T16:55:58Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/66072024-09-27T18:42:51Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19611col_20.500.12105_19609
Repisalud
author
Moya-Alonso, Laura
author
Herrador, Zaida
author
Ta Tang, Thuy-Huong
author
Rubio Muñoz, Jose Miguel
author
Perteguer-Prieto, Maria Jesus
author
Hernandez-Gonzalez, Ana
author
Garcia, Belen
author
Nguema, Rufino
author
Nguema, Justino
author
Ncogo, Policarpo
author
Garate, Teresa
author
Benito, Agustin
author
Sima, Anacleto
author
Aparicio, Pilar
funder
Agencia Española de Cooperación Internacional para el Desarrollo
funder
Academia Española de Dermatología y Venereología
funder
RETICS-Investigación colaborativa en Enfermedades Tropicales (RICET-ISCIII) (España)
2018-11-16T09:22:24Z
2018-11-16T09:22:24Z
2016-07-22
PLoS Negl Trop Dis. 2016; 10 (7): e0004829
10.1371/journal.pntd.0004829
1935-2735
1935-2735
PLoS neglected tropical diseases
27448085
http://hdl.handle.net/20.500.12105/6607
Onchocerciasis or "river blindness" is a chronic parasitic neglected tropical disease which is endemic both in mainland and insular Equatorial Guinea. We aim to estimate the current epidemiological situation of onchocerciasis in Bioko Island after vector elimination in 2005 and more than sixteen years of Community Directed Treatment with Ivermectin (CDTI) by using molecular and serological approaches for onchocerciasis diagnosis. A community-based cross-sectional study was carried out in Bioko Island from mid-January to mid-February 2014. A total of 544 study participants were recruited. A complete dermatological examination was performed and three skin snips were performed in every participant for parasitological and molecular assessments. Blood spots were also taken for determination of Ov16 IgG4 antibodies trough an "in-house" ELISA assay. Overall, we found 15 out of 522 individuals suffering any onchocerciasis specific cutaneous lesions and 16 out of 528 (3.0%) with onchocercal nodules in the skin. Nodules were significantly associated with age, being more common in subjects older than 10 years than in younger people (3.9% vs. 0%, p = 0.029). Regarding the onchocerciasis laboratory assessment, no positive parasitological test for microfilaria detection was found in the skin snips. The calculated seroprevalence through IgG4 serology was 7.9%. No children less than 10 years old were found to be positive for this test. Only one case was positive for Onchocerca volvulus (O. volvulus) after skin PCR. The present study points out that the on-going mass ivermectin treatment has been effective in reducing the prevalence of onchocerciasis and corroborates the interruption of transmission in Bioko Island. To our knowledge, this is the first time that accurate information through molecular and serological techniques is generated to estimate the onchocerciasis prevalence in this zone. Sustained support from the national program and appropriate communication and health education strategies to reinforce participation in CDTI activities are essential to ensure progress towards onchocerciasis elimination in the country.
eng
Evidence for Suppression of Onchocerciasis Transmission in Bioko Island, Equatorial Guinea
research article
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URL
https://repisalud.isciii.es/bitstreams/b257f8fe-97de-4065-8ec5-155c1e32e9cf/download
File
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application/pdf
EvidenceForSuppressionOf_2016.pdf
URL
https://repisalud.isciii.es/bitstreams/729a6a5b-1a78-4b1a-85d9-470be3460b21/download
File
MD5
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text/plain
EvidenceForSuppressionOf_2016.pdf.txt