2026-06-14T06:44:12Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/65822024-10-07T10:52:07Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608
Repisalud
author
Etxeberria, Jaione
author
Goicoa, Tomás
author
Lopez-Abente, Gonzalo
author
Riebler, Andrea
author
Ugarte, María Dolores
funder
Ministerio de Economía y Competitividad (España)
funder
Gobierno de Navarra (España)
2018-11-13T11:17:03Z
2018-11-13T11:17:03Z
2017
PLoS One. 2017; 12(2): e0169751.
10.1371/journal.pone.0169751
1932-6203
1932-6203
PLOS ONE
28199327
http://hdl.handle.net/20.500.12105/6582
Recently, the interest in studying pancreatic cancer mortality has increased due to its high lethality. In this work a detailed analysis of pancreatic cancer mortality in Spanish provinces was performed using recent data. A set of multivariate spatial gender-age-period-cohort models was considered to look for potential candidates to analyze pancreatic cancer mortality rates. The selected model combines features of APC (age-period-cohort) models with disease mapping approaches. To ensure model identifiability sum-to-zero constraints were applied. A fully Bayesian approach based on integrated nested Laplace approximations (INLA) was considered for model fitting and inference. Sensitivity analyses were also conducted. In general, estimated average rates by age, cohort, and period are higher in males than in females. The higher differences according to age between males and females correspond to the age groups [65, 70), [70, 75), and [75, 80). Regarding the cohort, the greatest difference between men and women is observed for those born between the forties and the sixties. From there on, the younger the birth cohort is, the smaller the difference becomes. Some cohort differences are also identified by regions and age-groups. The spatial pattern indicates a North-South gradient of pancreatic cancer mortality in Spain, the provinces in the North being the ones with the highest effects on mortality during the studied period. Finally, the space-time evolution shows that the space pattern has changed little over time.
eng
Spatial gender-age-period-cohort analysis of pancreatic cancer mortality in Spain (1990–2013)
journal article
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URL
https://repisalud.isciii.es/bitstreams/1f932fab-54b2-4f25-94bf-737036fc5d4e/download
File
MD5
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application/pdf
SpatialGenderAgePeriod_2017.pdf
URL
https://repisalud.isciii.es/bitstreams/6bf08036-b28d-43c7-89fb-dc3e43706c61/download
File
MD5
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text/plain
SpatialGenderAgePeriod_2017.pdf.txt