2026-08-29T16:26:12Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/65722024-11-28T16:10:08Zcom_20.500.12105_19604com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19605col_20.500.12105_16938col_20.500.12105_16980
Repisalud
author
Torralba, Daniel
author
Baixauli, Francesc
author
Villarroya-Beltri, Carolina
author
Fernandez-Delgado, Irene
author
Latorre-Pellicer, Ana
author
Acin-Perez, Rebeca
author
Martin-Cofreces, Noa B.
author
Jaso-Tamame, Angel Luis
author
Iborra, Salvador
author
Jorge, Inmaculada
author
Gonzalez-Aseguinolaza, Gloria
author
Garaude, Johan
author
Vicente-Manzanares, Miguel
author
Enriquez, Jose Antonio
author
Mittelbrunn, Maria
author
Sanchez-Madrid, Francisco
funder
Ministerio de Economía y Competitividad (España)
funder
Comunidad de Madrid (España)
funder
Centro de Investigación Biomedica en Red - CIBER
funder
Unión Europea. Comisión Europea
funder
Instituto de Salud Carlos III
funder
Fundación ProCNIC
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
2018-11-05T11:58:20Z
2018-11-05T11:58:20Z
2018
Nat Commun. 2018; 9(1):2658
10.1038/s41467-018-05077-9
2041-1723
Nature Communications
29985392
http://hdl.handle.net/20.500.12105/6572
Interaction of T cell with antigen-bearing dendritic cells (DC) results in T cell activation, but whether this interaction has physiological consequences on DC function is largely unexplored. Here we show that when antigen-bearing DCs contact T cells, DCs initiate antipathogenic programs. Signals of this interaction are transmitted from the T cell to the DC, through extracellular vesicles (EV) that contain genomic and mitochondrial DNA, to induce antiviral responses via the cGAS/STING cytosolic DNA-sensing pathway and expression of IRF3-dependent interferon regulated genes. Moreover, EV-treated DCs are more resistant to subsequent viral infections. In summary, our results show that T cells prime DCs through the transfer of exosomal DNA, supporting a specific role for antigen-dependent contacts in conferring protection to DCs against pathogen infection. The reciprocal communication between innate and adaptive immune cells thus allow efficacious responses to unknown threats.
eng
MITOCHONDRIAL-DNA
IMMUNOLOGICAL SYNAPSE
IMMUNE-RESPONSES
CANCER-CELLS
IN-VIVO
KAPPA-B
EXOSOMES
RELEASE
INNATE
IDENTIFICATION
Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts
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