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oai:repisalud.isciii.es:20.500.12105/65722024-11-28T16:10:08Zcom_20.500.12105_19604com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19605col_20.500.12105_16938col_20.500.12105_16980

00925njm 22002777a 4500 dc Torralba, Daniel author Baixauli, Francesc author Villarroya-Beltri, Carolina author Fernandez-Delgado, Irene author Latorre-Pellicer, Ana author Acin-Perez, Rebeca author Martin-Cofreces, Noa B. author Jaso-Tamame, Angel Luis author Iborra, Salvador author Jorge, Inmaculada author Gonzalez-Aseguinolaza, Gloria author Garaude, Johan author Vicente-Manzanares, Miguel author Enriquez, Jose Antonio author Mittelbrunn, Maria author Sanchez-Madrid, Francisco author 2018 Interaction of T cell with antigen-bearing dendritic cells (DC) results in T cell activation, but whether this interaction has physiological consequences on DC function is largely unexplored. Here we show that when antigen-bearing DCs contact T cells, DCs initiate antipathogenic programs. Signals of this interaction are transmitted from the T cell to the DC, through extracellular vesicles (EV) that contain genomic and mitochondrial DNA, to induce antiviral responses via the cGAS/STING cytosolic DNA-sensing pathway and expression of IRF3-dependent interferon regulated genes. Moreover, EV-treated DCs are more resistant to subsequent viral infections. In summary, our results show that T cells prime DCs through the transfer of exosomal DNA, supporting a specific role for antigen-dependent contacts in conferring protection to DCs against pathogen infection. The reciprocal communication between innate and adaptive immune cells thus allow efficacious responses to unknown threats. Nat Commun. 2018; 9(1):2658 2041-1723 http://hdl.handle.net/20.500.12105/6572 29985392 10.1038/s41467-018-05077-9 Nature Communications MITOCHONDRIAL-DNA IMMUNOLOGICAL SYNAPSE IMMUNE-RESPONSES CANCER-CELLS IN-VIVO KAPPA-B EXOSOMES RELEASE INNATE IDENTIFICATION Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts