2026-04-29T04:08:49Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/65702024-11-28T15:57:25Zcom_20.500.12105_19604com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19605col_20.500.12105_16938
Repisalud
author
Enamorado, Michel
author
Khouili, Sofia C.
author
Iborra, Salvador
author
Sancho, David
funder
Ministerio de Economía, Industria y Competitividad (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Educación, Cultura y Deporte (España)
funder
Centro Nacional de Investigaciones Cardiovasculares Carlos III (España)
funder
Agencia Estatal de Investigación (España)
funder
Comunidad de Madrid (España)
funder
Instituto de Salud Carlos III
funder
Fondation ACTERIA (Acting on European Research in Immunology and Allergology)
funder
Atresmedia
funder
Fundación La Marató TV3
funder
Unión Europea. Comisión Europea
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Fundación ProCNIC
2018-11-05T11:58:20Z
2018-11-05T11:58:20Z
2018
Front Immunol. 2018; 9:1751
1664-3224
http://hdl.handle.net/20.500.12105/6570
30108585
10.3389/fimmu.2018.01751
Frontiers in Immunology
Tissue-resident memory CD8(+) T (Trm) cells define a distinct non-recirculating subset. Trm cells constitute a first line of defense against local infections in barrier tissues, but they are also found in non-barrier tissues and play a role in antitumor immunity. Their differentiation in tissues and their phenotypical, transcriptional, and functional characteristics are the object of active research. Herein, we will discuss the potential existence of committed CD8(+) Trm precursors and the genealogy of memory CD8(+) T cell subsets. In addition to the priming of naive T cells, there is some plasticity of antigen-experienced effector and memory T cell subsets to generate Trm precursors. Local inflammation, antigen presentation, and cytokines drive Trm differentiation. It is of prime interest how specific dendritic cell subsets modulate priming and differentiation of Trm cells, as well as their reactivation within tissues. Research on how we can manipulate generation of memory T cells subsets is key for improved vaccination strategies.
eng
Memory CD8(+) T cell
Circulating memory
Tissue-resident memory
Infection
Plasticity
Priming
Differentiation
Dendritic cells
TUMOR-INFILTRATING LYMPHOCYTES
ADAPTIVE IMMUNE-RESPONSES
RESIDENT MEMORY
CUTTING EDGE
NONLYMPHOID TISSUES
VIRAL-INFECTION
RECALL RESPONSES
LOCAL ANTIGEN
TGF-BETA
RM CELLS
Genealogy, Dendritic Cell Priming, and Differentiation of Tissue-esident Memory CD8(+) T Cells
journal article
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https://repisalud.isciii.es/bitstreams/f11ecb97-e668-4daa-b4dc-6cc1b1083e82/download
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GenealogyDendriticCellPriming_2018.pdf
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File
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b19b4ee8a8800b81f4ef96638f6095ed
65297
text/plain
GenealogyDendriticCellPriming_2018.pdf.txt