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oai:repisalud.isciii.es:20.500.12105/65702024-11-28T15:57:25Zcom_20.500.12105_19604com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19605col_20.500.12105_16938

00925njm 22002777a 4500 dc Enamorado, Michel author Khouili, Sofia C. author Iborra, Salvador author Sancho, David author 2018 Tissue-resident memory CD8(+) T (Trm) cells define a distinct non-recirculating subset. Trm cells constitute a first line of defense against local infections in barrier tissues, but they are also found in non-barrier tissues and play a role in antitumor immunity. Their differentiation in tissues and their phenotypical, transcriptional, and functional characteristics are the object of active research. Herein, we will discuss the potential existence of committed CD8(+) Trm precursors and the genealogy of memory CD8(+) T cell subsets. In addition to the priming of naive T cells, there is some plasticity of antigen-experienced effector and memory T cell subsets to generate Trm precursors. Local inflammation, antigen presentation, and cytokines drive Trm differentiation. It is of prime interest how specific dendritic cell subsets modulate priming and differentiation of Trm cells, as well as their reactivation within tissues. Research on how we can manipulate generation of memory T cells subsets is key for improved vaccination strategies. Front Immunol. 2018; 9:1751 1664-3224 http://hdl.handle.net/20.500.12105/6570 30108585 10.3389/fimmu.2018.01751 Frontiers in Immunology Memory CD8(+) T cell Circulating memory Tissue-resident memory Infection Plasticity Priming Differentiation Dendritic cells TUMOR-INFILTRATING LYMPHOCYTES ADAPTIVE IMMUNE-RESPONSES RESIDENT MEMORY CUTTING EDGE NONLYMPHOID TISSUES VIRAL-INFECTION RECALL RESPONSES LOCAL ANTIGEN TGF-BETA RM CELLS Genealogy, Dendritic Cell Priming, and Differentiation of Tissue-esident Memory CD8(+) T Cells