2026-08-29T14:25:07Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/65692024-09-27T10:07:21Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19607
Repisalud
author
Cal-Gonzalez, Jacobo
author
Vaquero, Juan Jose
author
Herraiz, Joaquin L.
author
Perez-Liva, Mailyn
author
Soto-Montenegro, Maria Luisa
author
Pena-Zalbidea, Santiago
author
Desco, Manuel
author
Udias, Jose Manuel
funder
Ministerio de Ciencia e Innovación (España)
funder
Ministerio de Economía y Competitividad (España)
funder
Fundación Alicia Koplowitz
funder
Comunidad de Madrid (España)
funder
Unión Europea. Comisión Europea
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
2018-11-05T11:58:19Z
2018-11-05T11:58:19Z
2018
Mol Imaging Biol. 2018; 20(4):584-593
10.1007/s11307-018-1161-7
1860-2002
1536-1632
Molecular Imaging and Biology
29352372
http://hdl.handle.net/20.500.12105/6569
Image quality of positron emission tomography (PET) tracers that emits high-energy positrons, such as Ga-68, Rb-82, or I-124, is significantly affected by positron range (PR) effects. PR effects are especially important in small animal PET studies, since they can limit spatial resolution and quantitative accuracy of the images. Since generators accessibility has made Ga-68 tracers wide available, the aim of this study is to show how the quantitative results of [Ga-68]DOTA-labeled PET/X-ray computed tomography (CT) imaging of neuroendocrine tumors in mice can be improved using positron range correction (PRC). Eighteen scans in 12 mice were evaluated, with three different models of tumors: PC12, AR42J, and meningiomas. In addition, three different [Ga-68]DOTA-labeled radiotracers were used to evaluate the PRC with different tracer distributions: [Ga-68]DOTANOC, [Ga-68]DOTATOC, and [Ga-68]DOTATATE. Two PRC methods were evaluated: a tissue-dependent (TD-PRC) and a tissue-dependent spatially-variant correction (TDSV-PRC). Taking a region in the liver as reference, the tissue-to-liver ratio values for tumor tissue (TLRtumor), lung (TLRlung), and necrotic areas within the tumors (TLRnecrotic) and their respective relative variations (Delta TLR) were evaluated. All TLR values in the PRC images were significantly different (p < 0.05) than the ones from non-PRC images. The relative differences of the tumor TLR values, respect to the case with no PRC, were Delta TLRtumor 87 +/- 41 \% (TD-PRC) and 85 +/- 46 \% (TDSV-PRC). TLRlung decreased when applying PRC, being this effect more remarkable for the TDSV-PRC method, with relative differences respect to no PRC: Delta TLRlung = - 45 +/- 24 (TD-PRC), - 55 +/- 18 (TDSV-PRC). TLRnecrotic values also decreased when using PRC, with more noticeable differences for TD-PRC: Delta TLRnecrotic = - 52 +/- 6 (TD-PRC), - 48 +/- 8 (TDSV-PRC). The PRC methods proposed provide a significant quantitative improvement in [Ga-68]DOTA-labeled PET/CT imaging of mice with neuroendocrine tumors, hence demonstrating that these techniques could also ameliorate the deleterious effect of the positron range in clinical PET imaging.
eng
[Ga-68]DOTA-labeled radiotracers
Positron range correction
Small animal PET/CT
PET image reconstruction
EMISSION-TOMOGRAPHY
PRECLINICAL EVALUATION
MATHEMATICAL REMOVAL
SPATIAL-RESOLUTION
MAGNETIC-FIELD
SHINE-THROUGH
IMAGE-QUALITY
3D PET
RECONSTRUCTION
SYSTEM
Improving PET Quantification of Small Animal [Ga-68]DOTA-Labeled PET/CT Studies by Using a CT-Based Positron Range Correction
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ImprovingPETQuantificationofSmall_2018.pdf
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ImprovingPETQuantificationofSmall_2018_MOESM1_ESM.pdf
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ImprovingPETQuantificationofSmall_2018.pdf.txt
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