2026-08-29T14:17:35Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/65592024-11-29T16:57:35Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Muñoz Espin, Daniel author Rovira, Miguel author Galiana, Irene author Giménez, Cristina author Lozano-Torres, Beatriz author Paez-Ribes, Marta author Llanos, Susana author Chaib, Selim author Muñoz-Martín, Maribel author Ucero, Alvaro C author Garaulet, Guillermo author Mulero, Francisca author Dann, Stephen G author VanArsdale, Todd author Shields, David J author Bernardos, Andrea author Murguía, José Ramón author Martínez-Máñez, Ramón author Serrano Marugan , Manuel author 2018-09 Senescent cells accumulate in multiple aging-associated diseases, and eliminating these cells has recently emerged as a promising therapeutic approach. Here, we take advantage of the high lysosomal β-galactosidase activity of senescent cells to design a drug delivery system based on the encapsulation of drugs with galacto-oligosaccharides. We show that gal-encapsulated fluorophores are preferentially released within senescent cells in mice. In a model of chemotherapy-induced senescence, gal-encapsulated cytotoxic drugs target senescent tumor cells and improve tumor xenograft regression in combination with palbociclib. Moreover, in a model of pulmonary fibrosis in mice, gal-encapsulated cytotoxics target senescent cells, reducing collagen deposition and restoring pulmonary function. Finally, gal-encapsulation reduces the toxic side effects of the cytotoxic drugs. Drug delivery into senescent cells opens new diagnostic and therapeutic applications for senescence-associated disorders. EMBO Mol Med. 2018; 10 (9): pii: e9355. 10.15252/emmm.201809355 1757-4684 1757-4676 EMBO molecular medicine 30012580 http://hdl.handle.net/20.500.12105/6559 Chemotherapy Fibrosis Nanomedicine Palbociclib Senescence A versatile drug delivery system targeting senescent cells