2026-04-29T16:55:57Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/65512024-11-29T14:52:17Zcom_20.500.12105_19604com_20.500.12105_2051com_20.500.12105_2173col_20.500.12105_19605col_20.500.12105_19597
Repisalud
author
Rodriguez, Jose Manuel
author
Rodriguez Rivas, Juan
author
Di Domenico, Tomás
author
Vazquez, Jesús
author
Valencia, Alfonso
author
Tress ML, Michael L
funder
National Institutes of Health (Estados Unidos)
funder
Ministerio de Economía y Competitividad (España)
funder
Instituto Nacional de Bioinformatica (España)
funder
Instituto de Salud Carlos III
2018-10-30T10:32:28Z
2018-10-30T10:32:28Z
2018-01-04
Nucleic Acids Res. 2018; 46 (D1): D213 - D217.
10.1093/nar/gkx997
1362-4962
0305-1048
Nucleic acids research
29069475
http://hdl.handle.net/20.500.12105/6551
The APPRIS database (http://appris-tools.org) uses protein structural and functional features and information from cross-species conservation to annotate splice isoforms in protein-coding genes. APPRIS selects a single protein isoform, the 'principal' isoform, as the reference for each gene based on these annotations. A single main splice isoform reflects the biological reality for most protein coding genes and APPRIS principal isoforms are the best predictors of these main proteins isoforms. Here, we present the updates to the database, new developments that include the addition of three new species (chimpanzee, Drosophila melangaster and Caenorhabditis elegans), the expansion of APPRIS to cover the RefSeq gene set and the UniProtKB proteome for six species and refinements in the core methods that make up the annotation pipeline. In addition APPRIS now provides a measure of reliability for individual principal isoforms and updates with each release of the GENCODE/Ensembl and RefSeq reference sets. The individual GENCODE/Ensembl, RefSeq and UniProtKB reference gene sets for six organisms have been merged to produce common sets of splice variants.
eng
PROTEIN-CODING GENES
EVOLUTIONARY INFORMATION
FUNCTIONALLY IMPORTANT
SPLICE ISOFORMS
HUMAN GENOME
DATABASE
COMPLEXITY
PREDICTION
TOPOLOGY
PROJECT
APPRIS 2017: principal isoforms for multiple gene sets
journal article
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APPRIS2017principal_2018_.pdf
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APPRIS2017principal_2018_supp.pdf
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APPRIS2017principal_2018_.pdf.txt
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APPRIS2017principal_2018_supp.pdf.txt