2026-06-14T10:37:35Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/65432024-09-27T08:25:08Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Lopez-Santalla, Mercedes
author
Mancheno-Corvo, Pablo
author
Escolano, Amelia
author
Menta, Ramon
author
Delarosa, Olga
author
Redondo, Juan Miguel
author
Bueren, Juan A.
author
Dalemans, Wilfried
author
Lombardo, Eleuterio
author
Garin, Marina I.
funder
European Commission
funder
European Regional Development Fund
2018-10-26T07:59:27Z
2018-10-26T07:59:27Z
2018
Int J Mol Sci. 2018; 19(7):E1853
10.3390/ijms19071853
1422-0067
International Journal of Molecular Sciences
29937494
http://hdl.handle.net/20.500.12105/6543
Mesenchymal stem cells (MSCs) have emerged as a promising treatment for inflammatory diseases. The immunomodulatory effect of MSCs takes place both by direct cell-to-cell contact and by means of soluble factors that leads to an increased accumulation of regulatory immune cells at the sites of inflammation. Similar efficacy of MSCs has been described regardless of the route of administration used, the inflammation conditions and the major histocompatibility complex context. These observations raise the question of whether the migration of the MSCs to the inflamed tissues is a pre-requisite to achieve their beneficial effect. To address this, we examined the biodistribution and the efficacy of intraperitoneal luciferase-expressing human expanded adipose-derived stem cells (Luci-eASCs) in a mouse model of colitis. Luci-eASC-infused mice were stratified according to their response to the Luci-eASC treatment. According to the stratification criteria, there was a tendency to increase the bioluminescence signal in the intestine at the expense of a decrease in the bioluminescence signal in the liver in the ``responder´´ mice. These data thus suggest that the accumulation of the eASCs to the inflamed tissues is beneficial for achieving an optimal modulation of inflammation.
eng
Adipose-derived mesenchymal stem cells
Intraperitoneal therapy
Biodistribution
Efficacy
Colitis
SYSTEMIC-LUPUS-ERYTHEMATOSUS
STEM-CELLS
LYMPHOCYTE-PROLIFERATION
TRANSPLANTATION
PROTECT
RATS
MECHANISMS
ARTHRITIS
INJECTION
DISEASES
Comparative Analysis between the In Vivo Biodistribution and Therapeutic Efficacy of Adipose-Derived Mesenchymal Stromal Cells Administered Intraperitoneally in Experimental Colitis
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ComparativeAnalysisBetween_2018_suppl1.pdf
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