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oai:repisalud.isciii.es:20.500.12105/65432024-09-27T08:25:08Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Lopez-Santalla, Mercedes author Mancheno-Corvo, Pablo author Escolano, Amelia author Menta, Ramon author Delarosa, Olga author Redondo, Juan Miguel author Bueren, Juan A. author Dalemans, Wilfried author Lombardo, Eleuterio author Garin, Marina I. author 2018 Mesenchymal stem cells (MSCs) have emerged as a promising treatment for inflammatory diseases. The immunomodulatory effect of MSCs takes place both by direct cell-to-cell contact and by means of soluble factors that leads to an increased accumulation of regulatory immune cells at the sites of inflammation. Similar efficacy of MSCs has been described regardless of the route of administration used, the inflammation conditions and the major histocompatibility complex context. These observations raise the question of whether the migration of the MSCs to the inflamed tissues is a pre-requisite to achieve their beneficial effect. To address this, we examined the biodistribution and the efficacy of intraperitoneal luciferase-expressing human expanded adipose-derived stem cells (Luci-eASCs) in a mouse model of colitis. Luci-eASC-infused mice were stratified according to their response to the Luci-eASC treatment. According to the stratification criteria, there was a tendency to increase the bioluminescence signal in the intestine at the expense of a decrease in the bioluminescence signal in the liver in the ``responder´´ mice. These data thus suggest that the accumulation of the eASCs to the inflamed tissues is beneficial for achieving an optimal modulation of inflammation. Int J Mol Sci. 2018; 19(7):E1853 10.3390/ijms19071853 1422-0067 International Journal of Molecular Sciences 29937494 http://hdl.handle.net/20.500.12105/6543 Adipose-derived mesenchymal stem cells Intraperitoneal therapy Biodistribution Efficacy Colitis SYSTEMIC-LUPUS-ERYTHEMATOSUS STEM-CELLS LYMPHOCYTE-PROLIFERATION TRANSPLANTATION PROTECT RATS MECHANISMS ARTHRITIS INJECTION DISEASES Comparative Analysis between the In Vivo Biodistribution and Therapeutic Efficacy of Adipose-Derived Mesenchymal Stromal Cells Administered Intraperitoneally in Experimental Colitis