2026-04-29T04:08:58Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/65412024-09-27T09:07:10Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Groult, Hugo author Garcia-Alvarez, Isabel author Romero-Ramirez, Lorenzo author Nieto-Sampedro, Manuel author Herranz, Fernando author Fernandez-Mayoralas, Alfonso author Ruiz-Cabello, Jesus author 2018 The synthesis procedure of nanoparticles based on thermal degradation produces organic solvent dispersible iron oxide nanoparticles (OA-IONP) with oleic acid coating and unique physicochemical properties of the core. Some glycosides with hydrophilic sugar moieties bound to oleyl hydrophobic chains have antimitotic activity on cancer cells but reduced in vivo applications because of the intrinsic low solubility in physiological media, and are prone to enzymatic hydrolysis. In this manuscript, we have synthetized and characterized OA-IONP-based micelles encapsulated within amphiphilic bioactive glycosides. The glycoside-coated IONP micelles were tested as Magnetic Resonance Imaging (MRI) contrast agents as well as antimitotics on rat glioma (C6) and human lung carcinoma (A549) cell lines. Micelle antimitotic activity was compared with the activity of the corresponding free glycosides. In general, all OA-IONP-based micellar formulations of these glycosides maintained their anti-tumor effects, and, in one case, showed an unusual therapeutic improvement. Finally, the micelles presented optimal relaxometric properties for their use as T2-weighed MRI contrast agents. Our results suggest that these bioactive hydrophilic nano-formulations are theranostic agents with synergistic properties obtained from two entities, which separately are not ready for in vivo applications, and strengthen the possibility of using biomolecules as both a coating for OA-IONP micellar stabilization and as drugs for therapy. Nanomaterials (Basel). 2018; 8(8):567 2079-4991 http://hdl.handle.net/20.500.12105/6541 30044386 10.3390/nano8080567 Nanomaterials Glycoside Iron oxide nanoparticles Nanomicelles Antitumoral MULTIFUNCTIONAL MAGNETIC NANOPARTICLES DRUG-DELIVERY SUPERPARAMAGNETIC NANOPARTICLES BIOMEDICAL APPLICATIONS CONTRAST AGENTS CANCER-THERAPY SOLID TUMORS DIAGNOSIS NANOTECHNOLOGY EXPERIENCES Micellar Iron Oxide Nanoparticles Coated with Anti-Tumor Glycosides