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               <mods:identifier type="citation">PLoS One. 2018; 13(9):e0203817</mods:identifier>
               <mods:identifier type="doi">10.1371/journal.pone.0203817</mods:identifier>
               <mods:identifier type="issn">1932-6203</mods:identifier>
               <mods:identifier type="journal">PLOS ONE</mods:identifier>
               <mods:identifier type="pubmedID">30212543</mods:identifier>
               <mods:identifier type="uri">http://hdl.handle.net/20.500.12105/6533</mods:identifier>
               <mods:abstract>In scenarios where the use of a Computed Tomography (CT) is difficult, such as during surgery or in the ICU, the use of a C-arm system to generate tomographic information could contribute with interesting additional clinical information. Recent days are seeing the development of the so-called cone-beam CT (CBCT) based on advanced motorized isocentric C-arm systems. To be able to make use of more basic C-arm systems, apart from the geometric non-idealities common to any CBCT, we need to address other difficulties. First, the trajectory of the source-detector pair may differ from a circular path and the system may suffer mechanical strains that modify the relative positions of the source and detector for different projection angles. Second, and more importantly, the exact position of the source and detector elements may not be repeatable for consecutive rotations due to low mechanical precision, thus preventing an accurate geometrical calibration of the system. Finally, the limitation of the angular span and the difficulty of obtaining a high number of projections pose a great challenge to the image reconstruction. In this work, we present a novel method to adapt a standard C-arm, originally designed for planar imaging, to be used as a tomograph. The key parts of the new acquisition protocol are (1) a geometrical calibration method to compensate mechanical inaccuracies that prevent an accurate repetition of source-detector position between acquisitions, and (2) an advanced image reconstruction method able to deal with limited angle data, sparse projections and non-circular trajectories. Both methods exploit surface information from the patient, which can be obtained using a 3D surface scanner. The proposed method was evaluated with two real C-arm systems, based on an image intensifier and a flat panel detector respectively, showing the feasibility of the proposal.</mods:abstract>
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                  <mods:topic>BEAM COMPUTED-TOMOGRAPHY</mods:topic>
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                  <mods:topic>IMAGE GUIDANCE</mods:topic>
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                  <mods:topic>RECONSTRUCTION</mods:topic>
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                  <mods:title>Enabling tomography with low-cost C-arm systems</mods:title>
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