2026-04-29T04:09:04Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/65322024-09-27T09:34:03Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Rodriguez-Galan, Ana
author
Fernandez-Messina, Lola
author
Sanchez-Madrid, Francisco
funder
Ministerio de Economía y Competitividad (España)
funder
Centro de Investigación Biomedica en Red - CIBER
funder
Instituto de Salud Carlos III
funder
Comunidad de Madrid (España)
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Fundación ProCNIC
funder
Ministerio de Educación (España)
funder
Unión Europea. Comisión Europea
2018-10-26T07:59:25Z
2018-10-26T07:59:25Z
2018
Front Immunol. 2018; 9:2148
1664-3224
http://hdl.handle.net/20.500.12105/6532
30319616
10.3389/fimmu.2018.02148
Frontiers in Immunology
MiRNA targeting of key immunoregulatory molecules fine-tunes the immune response. This mechanism boosts or dampens immune functions to preserve homeostasis while supporting the full development of effector functions. MiRNA expression changes during T cell activation, highlighting that their function is constrained by a specific spatiotemporal frame related to the signals that induce T cell-based effector functions. Here, we update the state of the art regarding the miRNAs that are differentially expressed during T cell stimulation. We also revisit the existing data on miRNA function in T cell activation, with a special focus on the modulation of the most relevant immunoregulatory molecules.
eng
T cell activation
MicroRNAs (miRNAs)
Immunoregulatory molecules
miRNA signature
CD4
CD8
T lymphocyte
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
SYSTEMIC-LUPUS-ERYTHEMATOSUS
MICRORNA-MEDIATED REGULATION
IMMUNE-RESPONSE
TGF-BETA
MULTIPLE-SCLEROSIS
RNA-INTERFERENCE
GENE-EXPRESSION
DOWN-REGULATION
CYTOKINE PRODUCTION
Control of Immunoregulatory Molecules by miRNAs in T Cell Activation
journal article
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1808176
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ControlOfImmunoregulatoryMolecules_2018.pdf
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ControlOfImmunoregulatoryMolecules_2018.pdf.txt