2026-04-29T04:09:02Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/65322024-09-27T09:34:03Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Rodriguez-Galan, Ana author Fernandez-Messina, Lola author Sanchez-Madrid, Francisco author 2018 MiRNA targeting of key immunoregulatory molecules fine-tunes the immune response. This mechanism boosts or dampens immune functions to preserve homeostasis while supporting the full development of effector functions. MiRNA expression changes during T cell activation, highlighting that their function is constrained by a specific spatiotemporal frame related to the signals that induce T cell-based effector functions. Here, we update the state of the art regarding the miRNAs that are differentially expressed during T cell stimulation. We also revisit the existing data on miRNA function in T cell activation, with a special focus on the modulation of the most relevant immunoregulatory molecules. Front Immunol. 2018; 9:2148 1664-3224 http://hdl.handle.net/20.500.12105/6532 30319616 10.3389/fimmu.2018.02148 Frontiers in Immunology T cell activation MicroRNAs (miRNAs) Immunoregulatory molecules miRNA signature CD4 CD8 T lymphocyte EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS SYSTEMIC-LUPUS-ERYTHEMATOSUS MICRORNA-MEDIATED REGULATION IMMUNE-RESPONSE TGF-BETA MULTIPLE-SCLEROSIS RNA-INTERFERENCE GENE-EXPRESSION DOWN-REGULATION CYTOKINE PRODUCTION Control of Immunoregulatory Molecules by miRNAs in T Cell Activation