2026-06-14T10:38:30Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/65312024-09-27T10:07:09Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19607
Repisalud
author
Casquero-Veiga, Marta
author
García-García, David
author
Pascau, Javier
author
Desco, Manuel
author
Soto-Montenegro, Maria Luisa
funder
Instituto de Salud Carlos III
funder
Ministerio de Economía, Industria y Competitividad (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Fundación Mapfre
funder
Fundación Alicia Koplowitz
funder
Plan Nacional de Drogas (España)
funder
Comunidad de Madrid (España)
funder
Fundación Tatiana Pérez de Guzmán el Bueno
2018-10-26T07:59:25Z
2018-10-26T07:59:25Z
2018
PLoS One. 2018; 13(9):e0204740
10.1371/journal.pone.0204740
1932-6203
PLoS ONE
30261068
http://hdl.handle.net/20.500.12105/6531
Purpose The nucleus accumbens (NAcc) has been suggested as a possible target for deep brain stimulation (DBS) in the treatment of obesity. Our hypothesis was that NAcc-DBS would modulate brain regions related to reward and food intake regulation, consequently reducing the food intake and, finally, the weight gain. Therefore, we examined changes in brain glucose metabolism, weight gain and food intake after NAcc-DBS in a rat model of obesity. Procedures Electrodes were bilaterally implanted in 2 groups of obese Zucker rats targeting the NAcc. One group received stimulation one hour daily during 15 days, while the other remained as control. Weight and daily consumption of food and water were everyday registered the days of stimulation, and twice per week during the following month. Positron emission tomography (PET) studies with 2-deoxy-2-[F-18] fluoro-D-glucose (FDG) were performed 1 day after the end of DBS. PET data was assessed by statistical parametric mapping (SPM12) software and region of interest (ROI) analyses. Results NAcc-DBS lead to increased metabolism in the cingulate-retrosplenial-parietal association cortices, and decreased metabolism in the NAcc, thalamic and pretectal nuclei. Furthermore, ROIs analyses confirmed these results by showing a significant striatal and thalamic hypometabolism, and a cortical hypermetabolic region. However, NAcc-DBS did not induce a decrease in either weight gain or food intake. Conclusions NAcc-DBS led to changes in the metabolism of regions associated with cognitive and reward systems, whose impairment has been described in obesity.
eng
MESOLIMBIC DOPAMINE SYSTEM
SPRAGUE-DAWLEY RATS
SMALL-ANIMAL PET
RETROSPLENIAL CORTEX
CLINICAL ARTICLE
REWARD CIRCUITRY
NETWORK ACTIVITY
ZUCKER RATS
LEPTIN
MEMORY
Stimulating the nucleus accumbens in obesity: A positron emission tomography study after deep brain stimulation in a rodent model
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