2026-06-14T05:05:28Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/65182024-11-28T17:48:20Zcom_20.500.12105_19604com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19605col_20.500.12105_16961col_20.500.12105_16967col_20.500.12105_16983
Repisalud
author
Corella, Dolores
author
Sorli, Jose V.
author
Gonzlez, Jose I.
author
Ortega, Carolina
author
Fit, Montserrat
author
Bull, Monica
author
Martinez-Gonzalez, Miguel Angel
author
Ros, Emilio
author
Ars, Fernando
author
Lapetra, Jose
author
Gmez-Gracia, Enrique
author
Serra-Majem, Lluis
author
Ruiz-Gutierrez, Valentina
author
Fiol, Miquel
author
Coltell, Oscar
author
Vinyoles, Ernest
author
Pinto, Xavier
author
Marti, Amelia
author
Saiz, Carmen
author
Ordovas, Jose M
author
Estruch, Ramn
funder
Instituto de Salud Carlos III
funder
Ministerio de Economía y Competitividad (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
United States Department of Agriculture
funder
Generalitat Valenciana (España)
2018-10-25T08:19:46Z
2018-10-25T08:19:46Z
2014
Cardiovasc Diabetol. 2014; 13(1):5
10.1186/1475-2840-13-5
1475-2840
Cardiovascular Diabetology
http://hdl.handle.net/20.500.13003/11368
24393375
http://hdl.handle.net/20.500.12105/6518
Background: The Fas apoptotic pathway has been implicated in type 2 diabetes and cardiovascular disease. Although a polymorphism (rs7138803; G > A) near the Fas apoptotic inhibitory molecule 2 (FAIM2) locus has been related to obesity, its association with other cardiovascular risk factors and disease remains uncertain. Methods: We analyzed the association between the FAIM2-rs7138803 polymorphism and obesity, blood pressure and heart rate in 7,161 participants (48.3\% with type 2 diabetes) in the PREDIMED study at baseline. We also explored gene-diet interactions with adherence to the Mediterranean diet (MedDiet) and examined the effects of the polymorphism on cardiovascular disease incidence per diabetes status after a median 4.8-year dietary intervention (MedDiet versus control group) follow-up. Results: We replicated the association between the FAIM2-rs7138803 polymorphism and greater obesity risk (OR: 1.08; 95\% CI: 1.01-1.16; P = 0.011; per-A allele). Moreover, we detected novel associations of this polymorphism with higher diastolic blood pressure (DBP) and heart rate at baseline (B = 1.07; 95\% CI: 0.97-1.28 bmp in AA vs G-carriers for the whole population), that remained statistically significant even after adjustment for body mass index (P = 0.012) and correction for multiple comparisons. This association was greater and statistically significant in type-2 diabetic subjects (B = 1.44: 95\% CI: 0.23-2.56 bmp; P = 0.010 for AA versus G-carriers). Likewise, these findings were also observed longitudinally over 5-year follow-up. Nevertheless, we found no statistically significant gene-diet interactions with MedDiet for this trait. On analyzing myocardial infarction risk, we detected a nominally significant (P = 0.041) association in type-2 diabetic subjects (HR: 1.86; 95\% CI: 1.03-3.37 for AA versus G-carriers), although this association did not remain statistically significant following correction for multiple comparisons. Conclusions: We confirmed the FAIM2-rs7138803 relationship with obesity and identified novel and consistent associations with heart rate in particular in type 2 diabetic subjects. Furthermore, our results suggest a possible association of this polymorphism with higher myocardial infarction risk in type-2 diabetic subjects, although this result needs to be replicated as it could represent a false positive.
eng
Heart rate
FAIM2
Apoptosis
BODY-MASS INDEX
GENOME-WIDE ASSOCIATION
CORONARY-ARTERY-DISEASE
CARDIOVASCULAR-DISEASE
JAPANESE POPULATION
MEDITERRANEAN DIET
CAUSE MORTALITY
SOLUBLE FAS
VARIANTS
LOCI
Novel association of the obesity risk-allele near Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene with heart rate and study of its effects on myocardial infarction in diabetic participants of the PREDIMED trial
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