2026-07-21T10:47:33Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/65112024-11-29T16:21:50Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud author Klein, Alison P author Wolpin, Brian M author Risch, Harvey A author Stolzenberg-Solomon, Rachael Z author Mocci, Evelina author Zhang, Mingfeng author Canzian, Federico author Childs, Erica J author Hoskins, Jason W author Jermusyk, Ashley author Zhong, Jun author Wentzensen, Nicolas author Albanes, Demetrius author White, Emily author Yu, Herbert author Yu, Kai author Zheng, Wei author Kraft, Peter author Li, Donghui author Obazee, Ofure author Petersen, Gloria M author Brais, Lauren author Amundadottir, Laufey T author Andreotti, Gabriella author Arslan, Alan A author Buring, Julie author Babic, Ana author Bamlet, William R author Beane-Freeman, Laura author Chaffee, Kari G author Berndt, Sonja I author Blackford, Amanda author Chung, Charles C author Borges, Michael author Borgida, Ayelet author Bracci, Paige M author Brennan, Paul author Brenner, Hermann author Bueno-de-Mesquita, Bas author Campa, Daniele author Capurso, Gabriele author Cavestro, Giulia Martina author Cleary, Sean author Cotterchio, Michelle author Goodman, Gary E author Dijk, Frederike author Duell, Eric J author Foretova, Lenka author Hartge, Patricia author Fuchs, Charles author Funel, Niccola author Gallinger, Steven author Herman, Joseph author M Gaziano, J Michael author Gazouli, Maria author Holcatova, Ivana author Giles, Graham G author Giovannucci, Edward author Goggins, Michael author Goodman, Phyllis J author Hackert, Thilo author Haiman, Christopher author Hasan, Manal author Hegyi, Peter author Helzlsouer, Kathy J author Holly, Elizabeth A author Hoover, Robert author Kurtz, Robert J author Hung, Rayjean J author Jacobs, Eric J author Jamroziak, Krzysztof author Lee, I-Min author Janout, Vladimir author Kaaks, Rudolf author Khaw, Kay-Tee author Mambrini, Andrea author Klein, Eric A author Kogevinas, Manolis author Mannisto, Satu author Kooperberg, Charles author Kulke, Matthew H author Kupcinskas, Juozas author Laheru, Daniel author Landi, Stefano author Lawlor, Rita T author LeMarchand, Loic author Lu, Lingeng author Malats, Núria author Milne, Roger L author Mohelníková-Duchoňová, Beatrice author Rothman, Nathaniel author Neale, Rachel E author Neoptolemos, John P author Oberg, Ann L author Shu, Xiao-Ou author Olson, Sara H author Orlow, Irene author Pasquali, Claudio author Sund, Malin author Patel, Alpa V author Peters, Ulrike author Talar-Wojnarowska, Renata author Pezzilli, Raffaele author Porta, Miquel author Real Arribas, Francisco author Scelo, Ghislaine author Sesso, Howard D author Severi, Gianluca author Silverman, Debra author Smith, Jill P author Soucek, Pavel author Tavano, Francesca author Thornquist, Mark D author Zeleniuch-Jacquotte, Anne author Tobias, Geoffrey S author Van Den Eeden, Stephen K author Vashist, Yogesh author Chanock, Stephen author Visvanathan, Kala author Vodicka, Pavel author Wactawski-Wende, Jean author Chen, Fei author Wang, Zhaoming funder Lung Cancer Research Foundation funder Sol Goldman Pancreas Cancer Research Center funder Geoffrey Beene Foundation funder Arnold and Arlene Goldstein Family Foundation funder National Health and Medical Research Council (Australia) funder Czech Science Foundation funder Joan Rombauer Pancreatic Cancer Foundation funder NIH - National Cancer Institute (NCI) (Estados Unidos) funder Instituto de Salud Carlos III funder Ministerio de Ciencia y Tecnología (España) funder Red Temática de Investigación Cooperativa en Cáncer (RTICC) (España) funder Centro de Investigación Biomédica en Red - CIBERESP (Epidemiología y Salud Pública) 2018-10-25T07:55:15Z 2018-10-25T07:55:15Z 2018-02-08 Nat Commun. 2018; 9(1): 556. 10.1038/s41467-018-02942-5 2041-1723 2041-1723 Nature communications 29422604 http://hdl.handle.net/20.500.12105/6511 In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). Here, we find significant evidence of a novel association at rs78417682 (7p12/TNS3, P = 4.35 × 10-8). Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PANDoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36.33 (NOC2L, P = 8.36 × 10-14), rs2941471 at 8q21.11 (HNF4G, P = 6.60 × 10-10), rs4795218 at 17q12 (HNF1B, P = 1.32 × 10-8), and rs1517037 at 18q21.32 (GRP, P = 3.28 × 10-8). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA. Expression quantitative trait locus analysis in three independent pancreatic data sets provides molecular support of NOC2L as a pancreatic cancer susceptibility gene. eng BODY-MASS INDEX ASSOCIATION ANALYSES GENE-EXPRESSION TRANSCRIPTION FACTORS RISK IMPUTATION DISEASE ADENOCARCINOMA Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer journal article 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 URL https://repisalud.isciii.es/bitstreams/13a75f5c-cb9d-460b-b1c5-3dc67b23f4fd/download File MD5 a1b4fa388504dd694fc470d893dca402 1861125 application/pdf Genomewidemetaanalysis_2018.pdf URL https://repisalud.isciii.es/bitstreams/822b171b-c6ed-486b-86e4-9fb0fbc382b5/download File MD5 07fd80fa3236b9d251a15d74d86ad4d6 1638452 application/pdf Genomewidemeta_2018_MOESM1_ESM.pdf URL https://repisalud.isciii.es/bitstreams/2234de3c-5aeb-4cf0-ba09-281ba6c23e83/download File MD5 445f322308b13b06d23cb0e5bd4f9c16 233323 application/pdf Genomewidemeta_2018_MOESM2_ESM.pdf URL https://repisalud.isciii.es/bitstreams/33e3e449-4343-495d-8848-19b1d123f323/download File MD5 58545509988ab352fd610163be15f2c5 78541 text/plain Genomewidemetaanalysis_2018.pdf.txt URL https://repisalud.isciii.es/bitstreams/643dc444-3f2b-4266-ba4e-74ae8ec2696d/download File MD5 06db3fbde778adfcef917e88dd0baa47 55811 text/plain Genomewidemeta_2018_MOESM1_ESM.pdf.txt URL https://repisalud.isciii.es/bitstreams/0d448dc3-6495-4689-9c4a-d6f1778b49a8/download File MD5 7e3a66c618663c67602f2b953d5513ed 18934 text/plain Genomewidemeta_2018_MOESM2_ESM.pdf.txt