2026-05-20T23:33:00Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/65012024-09-27T08:12:22Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Martinez-Sanchez, Noelia
author
Seoane-Collazo, Patricia
author
Contreras, Cristina
author
Varela, Luis
author
Villarroya, Joan
author
Rial-Pensado, Eva
author
Buque, Xabier
author
Aurrekoetxea, Igor
author
Delgado, Teresa C.
author
Vazquez-Martinez, Rafael
author
Gonzalez-Garcia, Ismael
author
Roa, Juan
author
Whittle, Andrew J.
author
Gomez-Santos, Beatriz
author
Velagapudi, Vidya
author
Loraine Tung, Y. C.
author
Morgan, Donald A.
author
Voshol, Peter J.
author
Martinez de Morentin, Pablo B.
author
Lopez-Gonzalez, Tania
author
Linares-Pose, Laura
author
Gonzalez, Francisco
author
Chatterjee, Krishna
author
Sobrino, Tomas
author
Medina-Gomez, Gema
author
Davis, Roger J.
author
Casals, Nuria
author
Oresic, Matej
author
Coll, Anthony P.
author
Vidal-Puig, Antonio
author
Mittag, Jens
author
Tena-Sempere, Manuel
author
Malagon, Maria M.
author
Dieguez, Carlos
author
Martinez-Chantar, Maria Luz
author
Aspichueta, Patricia
author
Rahmouni, Kamal
author
Nogueiras, Ruben
author
Sabio, Guadalupe
author
Villarroya, Francesc
author
Lopez, Miguel
funder
Unión Europea. Comisión Europea
funder
Xunta de Galicia (España)
funder
Regional Government of Andalusia (España)
funder
Basque Government (España)
funder
EITB - Radio Televisión Pública Vasca
funder
Instituto de Salud Carlos III
funder
Government of Catalonia (España)
funder
Fundación La Marató TV3
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Economía y Competitividad (España)
funder
Asociación Española Contra el Cáncer
funder
Medical Research Council (Reino Unido)
funder
Wellcome Trust
funder
Deutsche Forschungsgemeinschaft (Alemania)
funder
National Institutes of Health (Estados Unidos)
funder
American Heart Association
funder
Fraternal Order of Eagles (Estados Unidos)
funder
European Foundation for the Study of Diabetes
funder
Fundación AstraZeneca
funder
Atresmedia
funder
Fundación ProCNIC
funder
University of Iowa (Estados Unidos)
2018-10-19T08:00:44Z
2018-10-19T08:00:44Z
2017
Cell Metab. 2017; 26(1):212-229 e12
10.1016/j.cmet.2017.06.014
1932-7420
1550-4131
Cell Metabolism
28683288
http://hdl.handle.net/20.500.12105/6501
Thyroid hormones (THs) act in the brain to modulate energy balance. We
show that central triiodothyronine (T3) regulates de novo lipogenesis in
liver and lipid oxidation in brown adipose tissue (BAT) through the
parasympathetic (PSNS) and sympathetic nervous system (SNS),
respectively. Central T3 promotes hepatic lipogenesis with parallel
stimulation of the thermogenic program in BAT. The action of T3 depends
on AMP-activated protein kinase (AMPK)-induced regulation of two
signaling pathways in the ventromedial nucleus of the hypothalamus
(VMH): decreased ceramide-induced endoplasmic reticulum(ER) stress,
which promotes BAT thermogenesis, and increased c-Jun N-terminal kinase
(JNK) activation, which controls hepatic lipid metabolism. Of note,
ablation of AMPK alpha 1 in steroidogenic factor 1 (SF1) neurons of the
VMH fully recapitulated the effect of central T3, pointing to this
population in mediating the effect of central THs on metabolism.
Overall, these findings uncover the underlying pathways through which
central T3 modulates peripheral metabolism.
eng
DIET-INDUCED OBESITY
ADIPOSE-TISSUE THERMOGENESIS
RAT-LIVER
INSULIN-RESISTANCE
VLDL SECRETION
BROWN FAT
NEURONS
METABOLISM
RECEPTOR
HOMEOSTASIS
Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance
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