2026-08-29T16:26:12Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/65012024-09-27T08:12:22Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Martinez-Sanchez, Noelia author Seoane-Collazo, Patricia author Contreras, Cristina author Varela, Luis author Villarroya, Joan author Rial-Pensado, Eva author Buque, Xabier author Aurrekoetxea, Igor author Delgado, Teresa C. author Vazquez-Martinez, Rafael author Gonzalez-Garcia, Ismael author Roa, Juan author Whittle, Andrew J. author Gomez-Santos, Beatriz author Velagapudi, Vidya author Loraine Tung, Y. C. author Morgan, Donald A. author Voshol, Peter J. author Martinez de Morentin, Pablo B. author Lopez-Gonzalez, Tania author Linares-Pose, Laura author Gonzalez, Francisco author Chatterjee, Krishna author Sobrino, Tomas author Medina-Gomez, Gema author Davis, Roger J. author Casals, Nuria author Oresic, Matej author Coll, Anthony P. author Vidal-Puig, Antonio author Mittag, Jens author Tena-Sempere, Manuel author Malagon, Maria M. author Dieguez, Carlos author Martinez-Chantar, Maria Luz author Aspichueta, Patricia author Rahmouni, Kamal author Nogueiras, Ruben author Sabio, Guadalupe author Villarroya, Francesc author Lopez, Miguel author 2017 Thyroid hormones (THs) act in the brain to modulate energy balance. We show that central triiodothyronine (T3) regulates de novo lipogenesis in liver and lipid oxidation in brown adipose tissue (BAT) through the parasympathetic (PSNS) and sympathetic nervous system (SNS), respectively. Central T3 promotes hepatic lipogenesis with parallel stimulation of the thermogenic program in BAT. The action of T3 depends on AMP-activated protein kinase (AMPK)-induced regulation of two signaling pathways in the ventromedial nucleus of the hypothalamus (VMH): decreased ceramide-induced endoplasmic reticulum(ER) stress, which promotes BAT thermogenesis, and increased c-Jun N-terminal kinase (JNK) activation, which controls hepatic lipid metabolism. Of note, ablation of AMPK alpha 1 in steroidogenic factor 1 (SF1) neurons of the VMH fully recapitulated the effect of central T3, pointing to this population in mediating the effect of central THs on metabolism. Overall, these findings uncover the underlying pathways through which central T3 modulates peripheral metabolism. Cell Metab. 2017; 26(1):212-229 e12 10.1016/j.cmet.2017.06.014 1932-7420 1550-4131 Cell Metabolism 28683288 http://hdl.handle.net/20.500.12105/6501 DIET-INDUCED OBESITY ADIPOSE-TISSUE THERMOGENESIS RAT-LIVER INSULIN-RESISTANCE VLDL SECRETION BROWN FAT NEURONS METABOLISM RECEPTOR HOMEOSTASIS Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance