2026-04-29T04:08:43Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/64942024-09-27T08:43:55Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Matesanz, Nuria
author
Bernardo, Edgar
author
Acin-Perez, Rebeca
author
Manieri, Elisa
author
Perez-Sieira, Sonia
author
Hernandez-Cosido, Lourdes
author
Montalvo-Romeral, Valle
author
Mora, Alfonso
author
Rodriguez, Elena
author
Leiva-Vega, Luis
author
Lechuga-Vieco, Ana V.
author
Ruiz-Cabello, Jesus
author
Torres, Jorge L
author
Crespo-Ruiz, Maria
author
Centeno, Francisco
author
Alvarez, Clara V.
author
Marcos, Miguel
author
Enriquez, Jose Antonio
author
Nogueiras, Ruben
author
Sabio, Guadalupe
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
European Foundation for the Study of Diabetes
funder
Ministerio de Economía, Industria y Competitividad (España)
funder
Comunidad de Madrid (España)
funder
Instituto de Salud Carlos III
funder
Junta de Castilla y León (España)
funder
Xunta de Galicia (España)
funder
Government of Extremadura (España)
funder
Fundación ProCNIC
2018-10-19T08:00:42Z
2018-10-19T08:00:42Z
2017
Nat Commun. 2017; 8(1):856
2041-1723
http://hdl.handle.net/20.500.12105/6494
29021624
10.1038/s41467-017-00948-z
NATURE COMMUNICATIONS
Increasing the thermogenic capacity of adipose tissue to enhance
organismal energy expenditure is considered a promising therapeutic
strategy to combat obesity. Here, we report that expression of the p38
MAPK activator MKK6 is elevated in white adipose tissue of obese
individuals. Using knockout animals and shRNA, we show that Mkk6
deletion increases energy expenditure and thermogenic capacity of white
adipose tissue, protecting mice against diet-induced obesity and the
development of diabetes. Deletion of Mkk6 increases T3-stimulated UCP1
expression in adipocytes, thereby increasing their thermogenic capacity.
Mechanistically, we demonstrate that, in white adipose tissue, p38 is
activated by an alternative pathway involving AMPK, TAK, and TAB. Our
results identify MKK6 in adipocytes as a potential therapeutic target to
reduce obesity.
eng
ACTIVATED PROTEIN-KINASE
BODY-MASS INDEX
INSULIN-RESISTANCE
ADULT
HUMANS
ADAPTIVE THERMOGENESIS
HUMAN ADIPOCYTES
THYROID-FUNCTION
MAP KINASE
FAT
GENE
MKK6 controls T3-mediated browning of white adipose tissue
journal article
URL
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MKK6ControlsT3-mediatedBrowning_2017.pdf
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MKK6ControlsT3-mediatedBrowning_2017_SUPPL.pdf
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MKK6ControlsT3-mediatedBrowning_2017.pdf.txt
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MKK6ControlsT3-mediatedBrowning_2017_SUPPL.pdf.txt