2026-08-29T16:26:16Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/64932024-10-31T11:40:42Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Fernandez-Alvira, Juan Miguel
author
Fuster, Valentin
author
Pocock, Stuart
author
Sanz, Javier
author
Fernandez-Friera, Leticia
author
Laclaustra, Martin
author
Fernandez-Jimenez, Rodrigo
author
Mendiguren, Jose M
author
Fernandez-Ortiz, Antonio
author
Ibáñez, Borja
author
Bueno, Hector
funder
Centro Nacional de Investigaciones Cardiovasculares Carlos III (España)
funder
Banco Santander
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Economía, Industria y Competitividad (España)
funder
Fundación ProCNIC
funder
Unión Europea. Comisión Europea
funder
Unión Europea
funder
American Heart Association
funder
AstraZeneca
funder
Bristol-Myers Squibb
funder
Janssen Cilag
funder
Novartis
funder
Bayer Healthcare Pharmaceuticals-Bayer Pharma AG
funder
Pfizer
funder
Ferrer
funder
Servier
funder
Medscape
2018-10-19T08:00:42Z
2018-10-19T08:00:42Z
2017
J Am Coll Cardiol. 2017; 70(20):2463-2473
10.1016/j.jacc.2017.09.032
1558-3597
0735-1097
Journal of the American College of Cardiology
29145946
http://hdl.handle.net/20.500.12105/6493
BACKGROUND The ideal cardiovascular health score (ICHS) is recommended
for use in primary prevention. Simpler tools not requiring laboratory
tests, such as the Fuster-BEWAT (blood pressure [B], exercise [E],
weight [W], alimentation [A], and tobacco [T]) score (FBS), are
also available.
OBJECTIVES The purpose of this study was to compare the effectiveness of
ICHS and FBS in predicting the presence and extent of subclinical
atherosclerosis.
METHODS A total of 3,983 participants 40 to 54 years of age were
enrolled in the PESA (Progression of Early Subclinical Atherosclerosis)
cohort. Subclinical atherosclerosis was measured in right and left
carotids, abdominal aorta, right and left iliofemoral arteries, and
coronary arteries. Subjects were classified as having poor,
intermediate, or ideal cardiovascular health based on the number of
favorable ICHS or FBS.
RESULTS With poor ICHS and FBS as references, individuals with ideal
ICHS and FBS showed lower adjusted odds of having atherosclerotic
plaques (ICHS odds ratio [OR]: 0.41; 95\% confidence interval [CI]:
0.31 to 0.55 vs. FBS OR: 0.49; 95\% CI: 0.36 to 0.66), coronary artery
calcium (CACS) >= 1 (CACS OR: 0.41; 95\% CI: 0.28 to 0.60 vs. CACS OR:
0.53; 95\% CI: 0.38 to 0.74), higher number of affected territories (OR:
0.32; 95\% CI: 0.26 to 0.41 vs. OR: 0.39; 95\% CI: 0.31 to 0.50), and
higher CACS level (OR: 0.40; 95\% CI: 0.28 to 0.58 vs. OR: 0.52; 95\%
CI: 0.38 to 0.72). Similar levels of significantly discriminating
accuracy were found for ICHS and FBS with respect to the presence of
plaques (C-statistic: 0.694; 95\% CI: 0.678 to 0.711 vs. 0.692; 95\% CI:
0.676 to 0.709, respectively) and for CACS >= 1 (C-statistic: 0.782;
95\% CI: 0.765 to 0.800 vs. 0.780; 95\% CI: 0.762 to 0.798,
respectively).
CONCLUSIONS Both scores predict the presence and extent of subclinical
atherosclerosis with similar accuracy, highlighting the value of the FBS
as a simpler and more affordable score for evaluating the risk of
subclinical disease. (C) 2017 The Authors. Published by Elsevier on
behalf of the American College of Cardiology Foundation.
eng
Cardiovascular risk
Fuster-BEWAT score
Ideal cardiovascular health
Predictive tools
Subclinical atherosclerosis
CORONARY-ARTERY CALCIUM
DISEASE RISK
HEART
PROGRESSION
ASSOCIATION
PREVALENCE
MORTALITY
MARKERS
COHORT
MESA
Predicting Subclinical Atherosclerosis in Low-Risk Individuals Ideal
Cardiovascular Health Score and Fuster-BEWAT Score
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